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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

dc.rights.licenseopenen_US
dc.contributor.authorYIN, Zhuoran
dc.contributor.authorHERRON, Shawn
dc.contributor.authorSILVEIRA, Sebastian
dc.contributor.authorKLEEMANN, Kilian
dc.contributor.authorGAUTHIER, Christian
dc.contributor.authorMALLAH, Dania
dc.contributor.authorCHENG, Yiran
dc.contributor.authorMARGETA, Milica A.
dc.contributor.authorPITTS, Kristen M.
dc.contributor.authorBARRY, Jen-Li
dc.contributor.authorSUBRAMANIAN, Ayshwarya
dc.contributor.authorSHOREY, Hannah
dc.contributor.authorBRANDAO, Wesley
dc.contributor.authorDURAO, Ana
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELPECH, Jean-Christophe
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMADORE, Charlotte
dc.contributor.authorJEDRYCHOWSKI, Mark
dc.contributor.authorAJAY, Amrendra K.
dc.contributor.authorMURUGAIYAN, Gopal
dc.contributor.authorHERSH, Samuel W.
dc.contributor.authorIKEZU, Seiko
dc.contributor.authorIKEZU, Tsuneya
dc.contributor.authorBUTOVSKY, Oleg
dc.date.accessioned2023-10-03T13:32:54Z
dc.date.available2023-10-03T13:32:54Z
dc.date.issued2023-06-08
dc.identifier.issn1097-6256en_US
dc.identifier.urioai:crossref.org:10.1038/s41593-023-01355-y
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183866
dc.description.abstractEnMicroglia play a critical role in brain homeostasis and disease progression. In neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD), whose function is poorly understood. MicroRNA-155 (miR-155), enriched in immune cells, critically regulates MGnD. However, its role in Alzheimer’s disease (AD) pathogenesis remains unclear. Here, we report that microglial deletion of miR-155 induces a pre-MGnD activation state via interferon-γ (IFN-γ) signaling, and blocking IFN-γ signaling attenuates MGnD induction and microglial phagocytosis. Single-cell RNA-sequencing analysis of microglia from an AD mouse model identifies Stat1 and Clec2d as pre-MGnD markers. This phenotypic transition enhances amyloid plaque compaction, reduces dystrophic neurites, attenuates plaque-associated synaptic degradation and improves cognition. Our study demonstrates a miR-155-mediated regulatory mechanism of MGnD and the beneficial role of IFN-γ-responsive pre-MGnD in restricting neurodegenerative pathology and preserving cognitive function in an AD mouse model, highlighting miR-155 and IFN-γ as potential therapeutic targets for AD.
dc.language.isoENen_US
dc.sourcecrossref
dc.title.enIdentification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41593-023-01355-yen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37291336en_US
bordeaux.journalNature Neuroscienceen_US
bordeaux.page1196-1207en_US
bordeaux.volume26en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04227164
hal.version1
hal.date.transferred2023-10-03T13:32:57Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Neuroscience&rft.date=2023-06-08&rft.volume=26&rft.issue=7&rft.spage=1196-1207&rft.epage=1196-1207&rft.eissn=1097-6256&rft.issn=1097-6256&rft.au=YIN,%20Zhuoran&HERRON,%20Shawn&SILVEIRA,%20Sebastian&KLEEMANN,%20Kilian&GAUTHIER,%20Christian&rft.genre=article


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