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Long-term benzodiazepine prescription in treatment-resistant depression: A national FACE-TRD prospective study

dc.rights.licenseopenen_US
dc.contributor.authorFOND, Guillaume
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorFAUGERE, Melanie
dc.contributor.authorBOYER, Laurent
dc.contributor.authorPERI, Pauline
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierSoins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale [EA7479 SPURBO]
dc.contributor.authorSTEPHAN, Florian
dc.contributor.authorMOLIERE, Fanny
dc.contributor.authorANGUILL, Loic
dc.contributor.authorBENNABI, Djamila
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOUVARD, Alexandra
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierSoins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale [EA7479 SPURBO]
dc.contributor.authorWALTER, Michel
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorLLORCA, Pierre Michel
dc.contributor.authorGENTY, Jean Baptiste
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorHOLTZMANN, Jerome
dc.contributor.authorNGUON, Anne Sophie
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorREY, Romain
dc.contributor.authorHORN, Mathilde
dc.contributor.authorVAIVA, Guillaume
dc.contributor.authorHENNION, Vincent
dc.contributor.authorETAIN, Bruno
dc.contributor.authorEL-HAGE, Wissam
dc.contributor.authorCAMUS, Vincent
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorYRONDI, Antoine
dc.contributor.authorLANCON, Christophe
dc.contributor.authorRICHIERI, Raphaelle
dc.date.accessioned2023-10-03T09:12:39Z
dc.date.available2023-10-03T09:12:39Z
dc.date.issued2023-08-01
dc.identifier.issn0278-5846en_US
dc.identifier.urioai:crossref.org:10.1016/j.pnpbp.2023.110779
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183864
dc.description.abstractEnBackground: Benzodiazepine long-term use (BLTU) is a public health challenge. We lack data on the consequences of LBTU on the trajectory of treatment-resistant depression (TRD). Objective: To determine the prevalence of BLTU in a nationwide non-selected population of patients with TRD, to determine the rate of patients succeeding at withdrawing benzodiazepines at one year and to determine if persistent BLTU is associated with poorer mental health outcomes. Method: The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at one year. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at one year. Results: At baseline, 45.2% of the patients were classified in the BLTU group. In multivariate analysis, compared to patients without BLTU, patients with BLTU were more frequently classified in the "low physical activity" group (adjusted odds ratio (aOR) = 1.885, p = 0.036), and had higher primary healthcare consumption (B = 0.158, p = 0.031) independently of age, sex and antipsychotic consumption. We found no significant difference for personality traits, suicidal ideation, impulsivity, childhood trauma exposure, earlier age at first major depressive episode, anxiety and sleep disorders (all p > 0.05). Despite recommendations for withdrawal, <5% of BLTU patients withdraw benzodiazepines during the one-year follow-up. Persistent BLTU at one-year was associated with higher depression severity (B = 0.189, p = 0.029), higher clinical global severity (B = 0.210, p = 0.016), higher state-anxiety (B = 0.266, p = 0.003), impaired sleep quality (B = 0.249, p = 0.008), increased peripheral inflammation (B = 0.241, p = 0.027), lower functioning level (B = -0.240, p = 0.006), decreased processing speed (B = -0.195, p = 0.020) and verbal episodic memory (B = -0.178, p = 0.048), higher absenteeism and productivity loss (B = 0.595, p = 0.016) and lower subjective global health status (B = -0.198, p = 0.028). Conclusion: Benzodiazepines are over-prescribed in TRD (in almost a half of the patients). Despite recommendations for withdrawal and psychiatric follow-up, <5% of patients successfully stopped taking benzodiazepines at one-year. Maintaining BLTU may contribute to the worsening of clinical and cognitive symptoms and of daily functioning in TRD patients. Progressive and planed withdrawal of benzodiazepines seems therefore strongly recommended in TRD patients with BLTU. Pharmacological and non-pharmacological alternatives should be promoted when possible.
dc.language.isoENen_US
dc.sourcecrossref
dc.title.enLong-term benzodiazepine prescription in treatment-resistant depression: A national FACE-TRD prospective study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.pnpbp.2023.110779en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37120004en_US
bordeaux.journalProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
bordeaux.page110779en_US
bordeaux.volume126en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04225900
hal.version1
hal.date.transferred2023-10-03T09:12:43Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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