High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV.
| dc.rights.license | open | en_US |
| dc.contributor.author | BONNET, Maryline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GABILLARD, Delphine | |
| dc.contributor.author | DOMOUA, Serge | |
| dc.contributor.author | MUZOORA, Conrad | |
| dc.contributor.author | MESSOU, Eugène | |
| dc.contributor.author | SOVANNARITH, Samreth | |
| dc.contributor.author | NGUYEN, Duc Bang | |
| dc.contributor.author | BADJE, Anani | |
| dc.contributor.author | JUCHET, Sylvain | |
| dc.contributor.author | BUNNET, Dim | |
| dc.contributor.author | BORAND, Laurence | |
| dc.contributor.author | NATUKUNDA, Naome | |
| dc.contributor.author | TRAN, Thị Hong | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | ANGLARET, Xavier | |
| dc.contributor.author | LAUREILLARD, Didier | |
| dc.contributor.author | BLANC, François-Xavier | |
| dc.date.accessioned | 2023-09-26T15:11:12Z | |
| dc.date.available | 2023-09-26T15:11:12Z | |
| dc.date.issued | 2023-07-01 | |
| dc.identifier.issn | 1537-6591 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183804 | |
| dc.description.abstractEn | In people with HIV (PWH), the WHO-recommended tuberculosis four-symptom screen (W4SS) targeting those who need molecular rapid test may be suboptimal. We assessed the performance of different tuberculosis screening approaches in severely immunosuppressed PWH enrolled in the guided-treatment group of the STATIS trial (NCT02057796). Ambulatory PWH with no overt evidence of tuberculosis and CD4 cell count <100/µL were screened for tuberculosis prior to antiretroviral therapy (ART) initiation with W4SS, chest X-ray, urine lipoarabinomannan (LAM) test and sputum Xpert MTB/RIF® (Xpert). Correctly and wrongly identified cases by screening approaches were assessed overall and by CD4 count threshold (≤50 and 51-99 cells/µL). Of 525 enrolled participants (median CD4 cell count: 28/µL), 48 (9.9%) were diagnosed with tuberculosis at enrollment. Among participants with a negative W4SS, 16% had either a positive Xpert, a chest X-ray suggestive of tuberculosis or a positive urine LAM test. The combination of sputum Xpert and urine LAM test was associated with the highest proportion of participants correctly identified as tuberculosis (95.8%) and non-tuberculosis cases (95.4%), with proportions equally high among participants with CD4 counts above or below 50 cells/µL. Restricting the use of sputum Xpert, urine LAM test or chest X-ray to participants with a positive W4SS reduced the proportion of wrongly and correctly identified cases. There is a clear benefit to perform both sputum Xpert and urine LAM tests as tuberculosis screening in all severely immunosuppressed PWH prior to ART initiation, and not only in those with a positive W4SS. NCT02057796. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Tuberculosis | |
| dc.subject.en | HIV | |
| dc.subject.en | Screening | |
| dc.subject.en | Diagnosis | |
| dc.title.en | High performance of systematic combined urine LAM test and sputum Xpert MTB/RIF® for tuberculosis screening in severely immunosuppressed ambulatory adults with HIV. | |
| dc.title.alternative | Clin Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/cid/ciad125 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36883573 | en_US |
| bordeaux.journal | Clinical Infectious Diseases | en_US |
| bordeaux.page | 112-119 | en_US |
| bordeaux.volume | 77 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | GHIGS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Recherches sur le Sida et les Hépatites Virales | en_US |
| bordeaux.import.source | pubmed | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2023-07-01&rft.volume=77&rft.issue=1&rft.spage=112-119&rft.epage=112-119&rft.eissn=1537-6591&rft.issn=1537-6591&rft.au=BONNET,%20Maryline&GABILLARD,%20Delphine&DOMOUA,%20Serge&MUZOORA,%20Conrad&MESSOU,%20Eug%C3%A8ne&rft.genre=article |
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