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Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder

dc.rights.licenseopenen_US
dc.contributor.authorGUNEYKAYA, Dilansu
dc.contributor.authorUGURSU, Bilge
dc.contributor.authorLOGIACCO, Francesca
dc.contributor.authorPOPP, Oliver
dc.contributor.authorFEIKS, Maria Almut
dc.contributor.authorMEYER, Niklas
dc.contributor.authorWENDT, Stefan
dc.contributor.authorSEMTNER, Marcus
dc.contributor.authorCHERIF, Fatma
dc.contributor.authorGAUTHIER, Christian
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMADORE, Charlotte
dc.contributor.authorYIN, Zhuoran
dc.contributor.authorÇINAR, Özcan
dc.contributor.authorARSLAN, Taner
dc.contributor.authorGEREVICH, Zoltan
dc.contributor.authorMERTINS, Philipp
dc.contributor.authorBUTOVSKY, Oleg
dc.contributor.authorKETTENMANN, Helmut
dc.contributor.authorWOLF, Susanne A.
dc.date.accessioned2023-09-26T12:59:50Z
dc.date.available2023-09-26T12:59:50Z
dc.date.issued2023-07-01
dc.identifier.issn0889-1591en_US
dc.identifier.urioai:crossref.org:10.1016/j.bbi.2023.03.023
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183800
dc.description.abstractEnNeuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic heritable autism spectrum disorder (ASD) and cause alterations in both synaptic and behavioral phenotypes. Microglia, the resident CNS macrophages, are implicated in ASD development and progression. Here we studied the impact of NLGN4 loss in a mouse model, focusing on microglia phenotype and function in both male and female mice. NLGN4 depletion caused lower microglia density, less ramified morphology, reduced response to injury and purinergic signaling specifically in the hippocampal CA3 region predominantly in male mice. Proteomic analysis revealed disrupted energy metabolism in male microglia and provided further evidence for sexual dimorphism in the ASD associated microglial phenotype. In addition, we observed impaired gamma oscillations in a sex-dependent manner. Lastly, estradiol application in male NLGN4-/- mice restored the altered microglial phenotype and function. Together, these results indicate that loss of NLGN4 affects not only neuronal network activity, but also changes the microglia state in a sex-dependent manner that could be targeted by estradiol treatment
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.sourcecrossref
dc.subject.enMicroglia
dc.subject.enPurinergic signaling
dc.subject.enAutism spectrum disorder
dc.subject.enGamma oscillation
dc.subject.enSex difference
dc.title.enSex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2023.03.023en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37001827en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page61-75en_US
bordeaux.volume111en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2023-07-01&rft.volume=111&rft.spage=61-75&rft.epage=61-75&rft.eissn=0889-1591&rft.issn=0889-1591&rft.au=GUNEYKAYA,%20Dilansu&UGURSU,%20Bilge&LOGIACCO,%20Francesca&POPP,%20Oliver&FEIKS,%20Maria%20Almut&rft.genre=article


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