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Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.

hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorKAMINSKI, Hannah
hal.structure.identifierService de virologie et d'immunologie biologique
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorGARRIGUE, Isabelle
IDREF: 12258953X
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorCOUZI, Lionel
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorTATON, Benjamin
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBACHELET, Thomas
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
dc.contributor.authorMOREAU, Jean-François
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
dc.contributor.authorDECHANET-MERVILLE, Julie
IDREF: 061667994
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierEpidémiologie et Biostatistique [Bordeaux]
dc.contributor.authorTHIÉBAUT, Rodolphe
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
dc.contributor.authorMERVILLE, Pierre
dc.date.accessioned2023-07-18T08:21:33Z
dc.date.available2023-07-18T08:21:33Z
dc.date.issued2015
dc.identifier.issn1046-6673
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183421
dc.description.abstractEnCytomegalovirus (CMV) infection in solid-organ transplantation is associated with increased morbidity and mortality, particularly if a CMV mutant strain with antiviral resistance emerges. Monitoring CMV-specific T cell response could provide relevant information for patient care. We and others have shown the involvement of Vδ2(neg) γδ T cells in controlling CMV infection. Here, we assessed if Vδ2(neg) γδ T cell kinetics in peripheral blood predict CMV infection resolution and emergence of a mutant strain in high-risk recipients of kidney transplants, including 168 seronegative recipients receiving organs from seropositive donors (D+R-) and 104 seropositive recipients receiving antithymocyte globulins (R+/ATG). Vδ2(neg) γδ T cell percentages were serially determined in patients grafted between 2003 and 2011. The growing phase of Vδ2(neg) γδ T cells was monitored in each infected patient, and the expansion rate during this phase was estimated individually by a linear mixed model. A Vδ2(neg) γδ T cell expansion rate of ˃0.06% per day predicted the growing phase. The time after infection at which an expansion rate of 0.06% per day occurred was correlated with the resolution of CMV DNAemia (r=0.91; P<0.001). At 49 days of antiviral treatment, Vδ2(neg) γδ T cell expansion onset was associated with recovery, whereas absence of expansion was associated with recurrent disease and DNAemia. The appearance of antiviral-resistant mutant CMV strains was associated with delayed Vδ2(neg) γδ T cell expansion (P<0.001). In conclusion, longitudinal surveillance of Vδ2(neg) γδ T cells in recipients of kidney transplants may predict CMV infection resolution and antiviral drug resistance.
dc.language.isoen
dc.publisherAmerican Society of Nephrology
dc.title.enSurveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.
dc.typeArticle de revueen_US
dc.identifier.doi10.1681/ASN.2014100985
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.page637-645
bordeaux.volume27
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue2
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01164667
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.date=2015&amp;rft.volume=27&amp;rft.issue=2&amp;rft.spage=637-645&amp;rft.epage=637-645&amp;rft.eissn=1046-6673&amp;rft.issn=1046-6673&amp;rft.au=KAMINSKI,%20Hannah&amp;GARRIGUE,%20Isabelle&amp;COUZI,%20Lionel&amp;TATON,%20Benjamin&amp;BACHELET,%20Thomas&amp;rft.genre=article


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