Phenotypic Profiles Among 72 Caucasian and Afro-Caribbean Patients with Antisynthetase Syndrome Involving Anti-PL7 or Anti-PL12 Autoantibodies.
dc.rights.license | open | en_US |
dc.contributor.author | ABEL, Aurore | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | LAZARO, Estibaliz | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | RALAZAMAHALEO, Mamy | |
dc.contributor.author | PIERRISNARD, Emma | |
dc.contributor.author | SUZON, Benoit | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | BONNET, Fabrice | |
hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
dc.contributor.author | MERCIÉ, Patrick | |
dc.contributor.author | MACEY, Julie | |
dc.contributor.author | AGOSSOU, Moustapha | |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
dc.contributor.author | VIALLARD, Jean-Francois | |
dc.contributor.author | DELIGNY, Christophe | |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
dc.contributor.author | RIVIÈRE, Etienne | |
dc.date.accessioned | 2023-07-18T08:07:33Z | |
dc.date.available | 2023-07-18T08:07:33Z | |
dc.date.issued | 2023-06-15 | |
dc.identifier.issn | 1879-0828 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183419 | |
dc.description.abstractEn | Antisynthetase syndrome (ASyS) is a rare autoimmune disease. We aimed to determine clinical, biological, radiological, and evolutive profiles of ASyS patients with anti-PL7 or anti-PL12 autoantibodies. We performed a retrospective study that included adults with overt positivity for anti-PL7/anti-PL12 autoantibodies and at least one Connors' criterion. Among 72 patients, 69% were women, 29 had anti-PL7 and 43 anti-PL12 autoantibodies, median age was 60.3 years, and median follow-up period was 52.2 months. At diagnosis, 76% of patients had interstitial lung disease, 61% had arthritis, 39% myositis, 25% Raynaud's phenomenon, 18% mechanic's hands, and 17% had fever. The most frequent pattern on initial chest computed tomography was non-specific interstitial pneumonia and 67% had fibrosis at last follow-up. During follow-up, 12 patients had pericardial effusion (18%), 19 had pulmonary hypertension (29%), 9 (12.5%) had neoplasms, and 14 (19%) died. Sixty-seven patients (93%) received at least one steroid or immunosuppressive drug. Patients with anti-PL12 autoantibodies were younger (p=0.01) and more frequently exhibited anti-SSA autoantibodies (p=0.01); patients with anti-PL7 autoantibodies had more severe weakness and higher maximum creatine kinase levels (p=0.03 and 0.04, respectively). Initial severe dyspnoea was more common in patients from the West Indies (p=0.009), with lower predicted values of forced vital capacity, forced expiratory volume in 1s, and total lung capacity (p=0.01, p=0.02, p=0.01, respectively) contributing to a more severe 'respiratory' initial presentation. The high mortality and significant numbers of cardiovascular events, neoplasms and lung fibrosis in anti-PL7/12 patients justify close monitoring and question addition of antifibrotic drugs. | |
dc.language.iso | EN | en_US |
dc.subject | Article clinique | |
dc.subject.en | Anti-PL12; Anti-PL7 autoantibody; Antisynthetase syndrome; Idiopathic inflammatory myopathy; tRNA synthetase autoantibody | |
dc.title.en | Phenotypic Profiles Among 72 Caucasian and Afro-Caribbean Patients with Antisynthetase Syndrome Involving Anti-PL7 or Anti-PL12 Autoantibodies. | |
dc.title.alternative | Eur J Intern Med | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.ejim.2023.06.012 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
dc.identifier.pubmed | 37330316 | en_US |
bordeaux.journal | European Journal of Internal Medicine | en_US |
bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-04164181 | |
hal.version | 1 | |
hal.date.transferred | 2023-07-18T08:07:42Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
workflow.import.source | pubmed | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Internal%20Medicine&rft.date=2023-06-15&rft.eissn=1879-0828&rft.issn=1879-0828&rft.au=ABEL,%20Aurore&LAZARO,%20Estibaliz&RALAZAMAHALEO,%20Mamy&PIERRISNARD,%20Emma&SUZON,%20Benoit&rft.genre=article |
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