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Signalling by senescent melanocytes hyperactivates hair growth.

dc.rights.licenseopenen_US
dc.contributor.authorWANG, Xiaojie
dc.contributor.authorRAMOS, Raul
dc.contributor.authorPHAN, Anne Q
dc.contributor.authorYAMAGA, Kosuke
dc.contributor.authorFLESHER, Jessica L
dc.contributor.authorJIANG, Shan
dc.contributor.authorOH, Ji Won
dc.contributor.authorJIN, Suoqin
dc.contributor.authorJAHID, Sohail
dc.contributor.authorKUAN, Chen-Hsiang
dc.contributor.authorNGUYEN, Truman Kt
dc.contributor.authorLIANG, Heidi Y
dc.contributor.authorSHETTIGAR, Nitish Udupi
dc.contributor.authorHOU, Renzhi
dc.contributor.authorTRAN, Kevin H
dc.contributor.authorNGUYEN, Andrew
dc.contributor.authorVU, Kimberly N
dc.contributor.authorPHUNG, Jennie L
dc.contributor.authorINGAL, Jonard P
dc.contributor.authorLEVITT, Katelyn M
dc.contributor.authorCAO, Xiaoling
dc.contributor.authorLIU, Yingzi
dc.contributor.authorDENG, Zhili
dc.contributor.authorTAGUCHI, Nobuhiko
dc.contributor.authorSCARFONE, Vanessa M
dc.contributor.authorWANG, Guangfang
dc.contributor.authorPAOLILLI, Kara Nicole
dc.contributor.authorWANG, Xiaoyang
dc.contributor.authorGUERRERO-JUAREZ, Christian F
dc.contributor.authorDAVIS, Ryan T
dc.contributor.authorGREENBERG, Elyse Noelani
dc.contributor.authorRUIZ-VEGA, Rolando
dc.contributor.authorVASUDEVA, Priya
dc.contributor.authorMURAD, Rabi
dc.contributor.authorWIDYASTUTI, Lily Halida Putri
dc.contributor.authorLEE, Hye-Lim
dc.contributor.authorMCELWEE, Kevin J
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorGADEAU, Alain-Pierre
dc.contributor.authorLAWSON, Devon A
dc.contributor.authorANDERSEN, Bogi
dc.contributor.authorMORTAZAVI, Ali
dc.contributor.authorYU, Zhengquan
dc.contributor.authorNIE, Qing
dc.contributor.authorKUNISADA, Takahiro
dc.contributor.authorKARIN, Michael
dc.contributor.authorTUCKERMANN, Jan
dc.contributor.authorESKO, Jeffrey D
dc.contributor.authorGANESAN, Anand K
dc.contributor.authorLI, Ji
dc.contributor.authorPLIKUS, Maksim V
dc.date.accessioned2023-07-18T07:53:06Z
dc.date.available2023-07-18T07:53:06Z
dc.date.issued2023-06-01
dc.identifier.issn1476-4687en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183415
dc.description.abstractEnNiche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity. Here, using genetic mouse models of nevi, we show that dermal clusters of senescent melanocytes drive epithelial hair stem cells to exit quiescence and change their transcriptome and composition, potently enhancing hair renewal. Nevus melanocytes activate a distinct secretome, enriched for signalling factors. Osteopontin, the leading nevus signalling factor, is both necessary and sufficient to induce hair growth. Injection of osteopontin or its genetic overexpression is sufficient to induce robust hair growth in mice, whereas germline and conditional deletions of either osteopontin or CD44, its cognate receptor on epithelial hair cells, rescue enhanced hair growth induced by dermal nevus melanocytes. Osteopontin is overexpressed in human hairy nevi, and it stimulates new growth of human hair follicles. Although broad accumulation of senescent cells, such as upon ageing or genotoxic stress, is detrimental for the regenerative capacity of tissue, we show that signalling by senescent cell clusters can potently enhance the activity of adjacent intact stem cells and stimulate tissue renewal. This finding identifies senescent cells and their secretome as an attractive therapeutic target in regenerative disorders.
dc.language.isoENen_US
dc.subjectArticle recherche
dc.subject.enAnimals
dc.subject.enMice
dc.subject.enHair
dc.subject.enHair Follicle
dc.subject.enHyaluronan Receptors
dc.subject.enMelanocytes
dc.subject.enNevus
dc.subject.enOsteopontin
dc.subject.enStem Cells
dc.subject.enSignal Transduction
dc.title.enSignalling by senescent melanocytes hyperactivates hair growth.
dc.title.alternativeNatureen_US
dc.typeArticle de revueen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed37344645en_US
bordeaux.journalNatureen_US
bordeaux.page808-817en_US
bordeaux.volume618en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue7966en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04164158
hal.version1
hal.date.transferred2023-07-18T07:54:24Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
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