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HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies

dc.contributor.authorFRANGE, Pierre
dc.contributor.authorASSOUMOU, Pierre
dc.contributor.authorDESCAMPS, Diane
dc.contributor.authorCHÉRET, Antoine
dc.contributor.authorGOUJARD, Cécile
dc.contributor.authorTRAN, Laurent
dc.contributor.authorGOUSSET, Marine
dc.contributor.authorAVETTAND-FENOËL, Véronique
dc.contributor.authorBOCKET, Laurence
dc.contributor.authorTRAN, Samira
dc.contributor.authorGUINARD, Jérôme
dc.contributor.authorMORAND-JOUBERT, Pierre
dc.contributor.authorNICOT, Florence
dc.contributor.authorPLANTIER, Jean-Christophe
dc.contributor.authorROGEZ, Sylvie
dc.contributor.authorWIRDEN, Pierre
dc.contributor.authorROUZIOUX, Christine
dc.contributor.authorMEYER, Laurence
dc.contributor.authorCHAIX, Marie-Laure
dc.contributor.authorABEL, S.
dc.contributor.authorABRAHAM, B.
dc.contributor.authorANTONIOTTI, A.
dc.contributor.authorARMERO, R.
dc.contributor.authorAUDHUY, B.
dc.contributor.authorAUMAITRE, H.
dc.contributor.authorBEAUCAIRE, G.
dc.contributor.authorBECK-WIRTH, G.
dc.contributor.authorBERGER, J.L.
dc.contributor.authorBERNARD, L.
dc.contributor.authorBEUSCART, C.
dc.contributor.authorBODARD, L.
dc.contributor.authorBOUCHAUD, O.
hal.structure.identifierinconnu
dc.contributor.authorBOUE, F.
dc.contributor.authorCABANE, J.-P.
dc.contributor.authorCABIÉ, A.
dc.contributor.authorCHAMPAGNE, H.
dc.contributor.authorCHENEAU, C.
dc.contributor.authorCHENNEBAULT, J.-M.
dc.contributor.authorCHERET, A.
dc.contributor.authorCHRISTIAN, B.
dc.contributor.authorCOMPAGNUCCI, A.
dc.contributor.authorDANELUZZI, V.
dc.contributor.authorDEBAB, Y.
dc.contributor.authorDELLAMONICA, P.
dc.contributor.authorDELFRAISSY, F.
dc.contributor.authorDEVIDAS, A.
dc.contributor.authorDIAB, G.
dc.contributor.authorDOLL, J.
dc.contributor.authorDROBACHEFF-THEBAUT, C.
dc.contributor.authorDUREL, A.
dc.contributor.authorESNAULT, L.
dc.contributor.authorFABA, L.
dc.contributor.authorFROGUEL, E.
dc.contributor.authorGARIPUY, D.
dc.contributor.authorGARRAIT, V.
dc.contributor.authorGEFFRAY, L.
dc.contributor.authorGENET, C.
dc.contributor.authorGENET, P.
dc.contributor.authorGÉRARD, L.
dc.contributor.authorGHOSN, J.
dc.contributor.authorGIRARD, J.
dc.contributor.authorGIRARD, Pascal
dc.contributor.authorGODIN-COLLET, C.
dc.contributor.authorHOCHEDEZ, P.
dc.contributor.authorHOEN, B.
dc.contributor.authorHOULBERT, D.
dc.contributor.authorJACOMET, C.
dc.contributor.authorJEANTILS, V.
dc.contributor.authorJIDAR, K.
dc.contributor.authorKLEMENT, E.
dc.contributor.authorLAFEUILLADE, A.
dc.contributor.authorLAUNAY, V.
dc.contributor.authorLEPRÊTRE, A.
dc.contributor.authorLEVY, Y.
dc.contributor.authorMAKHLOUFI, D.
dc.contributor.authorMALBEC, D.
dc.contributor.authorMARTHA, B.
dc.contributor.authorMAY, T.
dc.contributor.authorMERRIEN, D.
dc.contributor.authorMIAILHES, P.
dc.contributor.authorMIODOVSKI, C.
dc.contributor.authorMORLAT, P.
dc.contributor.authorMORTIER, E.
dc.contributor.authorNEAU, D.
dc.contributor.authorOBADIA, M.
dc.contributor.authorPATEY, O.
dc.contributor.authorPELLEGRIN, L.
dc.contributor.authorPERRONNE, V.
dc.contributor.authorPHILIBERT, P.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorPICHANCOURT, G.
dc.contributor.authorPIROTH, L.
dc.contributor.authorPOINSIGNON, Y.
dc.contributor.authorPOIZOT-MARTIN, I.
dc.contributor.authorPRAZUCK, T.
dc.contributor.authorPRENDKI, V.
dc.contributor.authorDU CLARY, F.
dc.contributor.authorQUINSAT, D.
hal.structure.identifierSTMicroelectronics
dc.contributor.authorREGNIER, A.
dc.contributor.authorREYNES, J.
dc.contributor.authorROSENTHAL, E.
dc.contributor.authorROUVEIX, E.
dc.contributor.authorSALMON, D.
dc.contributor.authorSALANVILLE, F.
dc.contributor.authorSCHMITT, L.
dc.contributor.authorSIMON-COUTELLIER, A.
dc.contributor.authorSOTTO, A.
dc.contributor.authorSOUALA, F.
dc.contributor.authorSTEIN, A.
dc.contributor.authorTIMSIT, F.
dc.contributor.authorDE TRUCHIS, P.
dc.contributor.authorULUDAG, A.
dc.contributor.authorVAILLANT, O.
dc.contributor.authorVERDON, R.
dc.contributor.authorVERLESCH-LANGLIN, A.
dc.contributor.authorVIARD, J.-P.
dc.contributor.authorVITTECOQ, D.
dc.contributor.authorWEISS, L.
dc.contributor.authorYÉNI, P.
dc.contributor.authorZUCMAN, D.
dc.contributor.authorALLAVENA, C.
dc.contributor.authorALLEGRE, T.
dc.contributor.authorAMRI, I.
dc.contributor.authorAUTRAN, B.
dc.contributor.authorBACCHUS, C.
dc.contributor.authorBLANC, C.
dc.contributor.authorBONNE, S.
dc.contributor.authorBONNE, B.
dc.contributor.authorBOUCHEZ, S.
hal.structure.identifierNivologie [UR NIGR]
dc.contributor.authorCHARLIER, C.
dc.contributor.authorCONSIGNY, H.
dc.contributor.authorDUVIVIER, C.
dc.contributor.authorFOURN, E.
dc.contributor.authorGUIROY, F.
dc.contributor.authorHULEUX, T.
dc.contributor.authorKATLAMA, C.
dc.contributor.authorLASCOUX, C.
dc.contributor.authorLEPLATOIS, A.
dc.contributor.authorLYAVANC, T.
dc.contributor.authorMOLINA, J.-M.
dc.contributor.authorNAQVI, A.
dc.contributor.authorNEMBOT, G.
dc.contributor.authorQUERTAINMONT, Y.
dc.contributor.authorRAFFI, F.
dc.contributor.authorSAMRI, A.
dc.contributor.authorSCHNEIDER, L.
dc.contributor.authorSEANG, S.
dc.contributor.authorSEKSIK, B.
dc.contributor.authorSHOAI-TEHRANI, M.
dc.contributor.authorSLAMA, L.
dc.contributor.authorVALENTIN, A.
dc.contributor.authorYAZDANPANAH, Y.
dc.contributor.authorALLOUI, C.
dc.contributor.authorAMIEL, C.
dc.contributor.authorANDRÉ, P.
dc.contributor.authorANDRÉ, E.
dc.contributor.authorANIES, G.
dc.contributor.authorBARIN, F.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBELLECAVE, P.
dc.contributor.authorBETTINGER, D.
dc.contributor.authorBOUVIER-ALIAS, M.
dc.contributor.authorBRUN-VÉZINET, F.
dc.contributor.authorCALMY, A.
dc.contributor.authorCALVEZ, V.
dc.contributor.authorCAVENG, W.
dc.contributor.authorCHAILLON, A.
dc.contributor.authorCHAPALAY, S.
dc.contributor.authorCHARPENTIER, C.
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorCOTTALORDA, J.
dc.contributor.authorDELAMARE, C.
dc.contributor.authorDELAUGERRE, C.
dc.contributor.authorDINA, J.
dc.contributor.authorSANTOS, G.
dc.contributor.authorFERRE, V.
dc.contributor.authorFLANDRE, P.
dc.contributor.authorFLEURY, H.
dc.contributor.authorFOURATI, S.
dc.contributor.authorGAILLE, C.
dc.contributor.authorGIRAUDEAU, G.
dc.contributor.authorGUIGON, A.
dc.contributor.authorHAIM-BOUKOBZA, S.
dc.contributor.authorLAGIER, E.
dc.contributor.authorLE GUILLOU-GUILLEMETTE, H.
dc.contributor.authorHENQUELL, C.
dc.contributor.authorIZOPET, Jacques
dc.contributor.authorLAMBERT-NICLOT, Lambert
dc.contributor.authorLEROUX, M.
dc.contributor.authorMAILLARD, A.
dc.contributor.authorMALET, I.
dc.contributor.authorMARCELIN, Marc
dc.contributor.authorMARQUE-JUILLET, S.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMASQUELIER, B.
dc.contributor.authorMIRAND, A.
dc.contributor.authorMORAND, P.
dc.contributor.authorMONTES, B
dc.contributor.authorMOUNA, L.
dc.contributor.authorNOEL, C.
dc.contributor.authorPALLIER, C.
dc.contributor.authorPEYTAVIN, G.
dc.contributor.authorPINSON-RECORDON, P.
dc.contributor.authorPOVEDA, J.
dc.contributor.authorRAYMOND, S.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorREIGADAS, S.
dc.contributor.authorROQUES, A.
dc.contributor.authorDE ROUGEMONT, A.
dc.contributor.authorROUSSEL, C.
dc.contributor.authorSCHMITT, P.
dc.contributor.authorSCHNEIDER, V.
dc.contributor.authorSCHVOERER, E.
dc.contributor.authorSIGNORI-SCHMUCK, A.
hal.structure.identifierCHU Pitié-Salpêtrière [AP-HP]
dc.contributor.authorSOULIÉ, C.
dc.contributor.authorTAMALET, C.
dc.contributor.authorTARDY, C.
dc.contributor.authorTRABAUD, A.
dc.contributor.authorVABRET, A.
dc.contributor.authorVALLET, S.
dc.contributor.authorYERLY, S.
dc.date.accessioned2023-07-13T10:42:59Z
dc.date.available2023-07-13T10:42:59Z
dc.date.issued2015-07-01
dc.identifier.issn0305-7453
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183392
dc.description.abstractEnBackground: Our study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12.Methods: HIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART combination.Results: Patients were mainly MSM (72.6%). Non-B variants were identified in 33.7% of patients. The proportion of TDR was estimated as 11.7% (95% CI 10.0-13.5). The prevalences of PI-, NRTI-, first-generation NNRTI and etravirine/rilpivirine-associated RAMs were 2.5%, 5.2%, 3.9% and 3.2%, respectively. Single, dual and triple class resistance was found in 9.6%, 1.0% and 1.1% of cases, respectively. Additionally, 5/331 strains isolated in 201012 had integrase inhibitor (II)-related RAMs (isolated E157Q mutation in all cases). TDR was more common among MSM than in other groups (12.9% versus 8.6%, P = 0.034), and in case of B versus non-B subtype infections (13.6% versus 7.9%, P = 0.002). The proportions of fully active combinations were >= 99.2%, >= 97.3% and >= 95.3% in cases of PI-, II- and NNRTI-based regimens, respectively. In 2010-12, the proportion of fully active efavirenz-based ART was lower in cases of subtype B versus non-B infection (P = 0.021).Conclusions: Compared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enResistance-associated mutations
dc.subject.enPrimary HIV infection
dc.subject.enHIV-1
dc.title.enHIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jac/dkv049
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Protistologie
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.page2084-2089
bordeaux.volume70
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue7
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01983697
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
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