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Towards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure.

dc.contributor.authorZEISEL, Mirjam B
dc.contributor.authorLUCIFORA, Julie
dc.contributor.authorMASON, William S
dc.contributor.authorSUREAU, Camille
dc.contributor.authorBECK, Jürgen
dc.contributor.authorLEVRERO, Massimo
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorKANN, Michael
dc.contributor.authorKNOLLE, Percy A
dc.contributor.authorBENKIRANE, Monsef
dc.contributor.authorDURANTEL, David
dc.contributor.authorMICHEL, Marie-Louise
dc.contributor.authorAUTRAN, Brigitte
dc.contributor.authorFRANÇOIS-LOÏC, Cosset
dc.contributor.authorSTRICK-MARCHAND, Hélène
dc.contributor.authorTRÉPO, Christian
dc.contributor.authorKAO, Jia-Horng
dc.contributor.authorCARRAT, Fabrice
dc.contributor.authorLACOMBE, Karine
dc.contributor.authorSCHINAZI, Raymond F
dc.contributor.authorBARRÉ-SINOUSSI, Françoise
dc.contributor.authorDELFRAISSY, Jean-François
dc.contributor.authorZOULIM, Fabien
dc.date.accessioned2023-07-13T07:25:54Z
dc.date.available2023-07-13T07:25:54Z
dc.date.issued2015-08
dc.identifier.issn0017-5749
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183390
dc.description.abstractEnHBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-of-the-art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.subject.meshAntiviral Agents
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshLiver Neoplasms
dc.subject.meshDNA, Viral
dc.subject.meshDisease Progression
dc.subject.meshGlobal Health
dc.subject.meshHepatitis B virus
dc.subject.meshHepatitis B, Chronic
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshLiver Cirrhosis
dc.title.enTowards an HBV cure: state-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure.
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/gutjnl-2014-308943
dc.subject.halSciences du Vivant [q-bio]
bordeaux.page1314-26
bordeaux.volume64
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue8
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01157784
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
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