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dc.rights.licenseopenen_US
dc.contributor.authorDUPIRE, C.
dc.contributor.authorCHENNELL, P.
dc.contributor.authorPEREIRA, B.
dc.contributor.authorCOURTIOL, N.
dc.contributor.authorBUJ, S.
dc.contributor.authorCUEFF, R.
dc.contributor.authorCRAUSTE-MANCIET, S.
dc.contributor.authorSAUTOU, V.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMORGAT, Clement
dc.date.accessioned2023-06-28T12:44:16Z
dc.date.available2023-06-28T12:44:16Z
dc.date.issued2023-02-15
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183231
dc.description.abstractEnThe sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [Tc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enRadiopharmaceuticals
dc.subject.enSyringes
dc.subject.enRubber
dc.title.enA proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-023-29923-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36792806en_US
bordeaux.journalScientific Reportsen_US
bordeaux.page2721en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamImagerie multimodale translationnelleen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04144593
hal.version1
hal.date.transferred2023-06-28T12:44:20Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2023-02-15&rft.volume=13&rft.issue=1&rft.spage=2721&rft.epage=2721&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=DUPIRE,%20C.&CHENNELL,%20P.&PEREIRA,%20B.&COURTIOL,%20N.&BUJ,%20S.&rft.genre=article


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