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Inventory of extended-spectrum-β-lactamase-producing Enterobacteriaceae in France as assessed by a multicenter study

dc.contributor.authorROBIN, F.
hal.structure.identifierLaboratoire de Bactériologie & CNR de la Résistance aux Antibiotiques
hal.structure.identifierUniversité d'Auvergne - Clermont-Ferrand I [UdA]
hal.structure.identifierMicrobes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
dc.contributor.authorBEYROUTHY, Racha
dc.contributor.authorBONACORSI, Stéphane
dc.contributor.authorAISSA, Nejla
dc.contributor.authorBRET, L.
dc.contributor.authorBRIEU, N.
dc.contributor.authorCATTOIR, Vincent
dc.contributor.authorCHAPUIS, A.
dc.contributor.authorCHARDON, Hubert
dc.contributor.authorDEGAND, N
dc.contributor.authorDOUCET-POPULAIRE, Florence
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorDUBOIS, V.
dc.contributor.authorFORTINEAU, Nicolas
dc.contributor.authorGRILLON, A.
dc.contributor.authorLANOTTE, Philippe
dc.contributor.authorLEYSSENE, David
dc.contributor.authorPATRY, Ivania
dc.contributor.authorPODGLAJEN, I
hal.structure.identifierService de Bacteriologie
dc.contributor.authorRECULE, C.
hal.structure.identifierLaboratoire de Bactériologie-Virologie-Hygiène
dc.contributor.authorROS, A.
dc.contributor.authorCOLOMB-COTINAT, M
dc.contributor.authorPONTIES, V.
dc.contributor.authorPLOY, Marie-Cecile
dc.contributor.authorBONNET, R
dc.date.accessioned2023-06-28T11:14:55Z
dc.date.available2023-06-28T11:14:55Z
dc.date.issued2017
dc.identifier.issn0066-4804
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183225
dc.description.abstractEnThe objective of this study was to perform an inventory of the ESBL-producing Enterobacteriaceae isolates responsible for infections in French hospitals, and to assess the mechanisms associated with ESBL diffusion.200 non-redundant ESBL-producing Enterobacteriaceae strains isolated from clinical samples were collected during a multi-centric study performed in 18 representative French hospitals. Antibiotic resistance genes were identified by PCR and sequencing experiments. The clonal relatedness between isolates was investigated by the Diversilab system. ESBL-encoding plasmids were compared by PCR-based-replicon-typing and plasmid-multi-locus-sequence-typing.CTX-M-15, CTX-M-1, CTX-M-14 and SHV-12 were the most prevalent ESBLs (8 to 46.5%). The three CTX-M-type EBSLs were significantly observed in Escherichia coli (37.1%, 24.2% and 21.8% respectively), and CTX-M-15 was the predominant ESBL in Klebsiella pneumoniae (81.1%). SHV-12 was associated with ESBL-encoding Enterobacter cloacae strains (37.9%). qnrB, aac(6')-Ib-cr and aac (3)-II genes were the main plasmid-mediated resistance genes, with prevalence varying between 19.5 and 45% according to the ESBLs. Molecular typing did not identify wide clonal diffusion. Plasmid analysis suggested the diffusion of few numbers of ESBL-encoding plasmids, especially in K. pneumoniae and E. cloacae However, the ESBL-encoding genes were observed in different plasmid replicons according to the bacterial species.The prevalence of ESBL subtypes is different according to the Enterobacteriaceae species. Plasmid spread is a key determinant of this epidemiology and the link observed between the ESBL-encoding plasmids and the bacterial host explain the differences observed in the Enterobacteriaceae species.
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights.urihttp://hal.archives-ouvertes.fr/licences/copyright/
dc.subjectgène de résistance
dc.subjectenterobacteriaceae
dc.subjectFrance
dc.subjectbeta lactamase
dc.subjectrésistance aux antibiotiques
dc.subject.enESBL
dc.subject.enplasmid-mediated quinolone resistance
dc.subject.enAAC(3)-II
dc.subject.enAAC(6’)-Ib
dc.subject.enplasmid
dc.subject.enenterobacteria
dc.subject.enresistance gene
dc.subject.enresistance to antibiotics
dc.title.enInventory of extended-spectrum-β-lactamase-producing Enterobacteriaceae in France as assessed by a multicenter study
dc.typeArticle de revueen_US
dc.identifier.doi10.1128/AAC.01911-16
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie
bordeaux.journalAntimicrobial Agents and Chemotherapyen_US
bordeaux.page13 p.
bordeaux.volume61
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue3
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01595458
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antimicrobial%20Agents%20and%20Chemotherapy&rft.date=2017&rft.volume=61&rft.issue=3&rft.spage=13%20p.&rft.epage=13%20p.&rft.eissn=0066-4804&rft.issn=0066-4804&rft.au=ROBIN,%20F.&BEYROUTHY,%20Racha&BONACORSI,%20St%C3%A9phane&AISSA,%20Nejla&BRET,%20L.&rft.genre=article


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