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Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation

dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de Biologie Moléculaire de la Cellule [LBMC]
dc.contributor.authorSALTEL, Frédéric
dc.contributor.authorGIESE, Alban
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorAZZI, Lamia
dc.contributor.authorELATMANI, Habiba
dc.contributor.authorCOSTET, Pierre
dc.contributor.authorEZZOUKHRY, Zakaria
dc.contributor.authorDUGOT-SENANT, Nathalie
dc.contributor.authorMIQUEROL, Lucile
dc.contributor.authorBOUSSADIA, Oréda
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorWODRICH, Harald
dc.contributor.authorDUBUS, Pierre
dc.contributor.authorJACQUEMIN-SABLON, Hélène
dc.date.accessioned2023-06-28T10:41:01Z
dc.date.available2023-06-28T10:41:01Z
dc.date.issued2017-05-15
dc.identifier.issn0021-9533en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183220
dc.description.abstractEnUnr (officially known as CSDE1) is a cytoplasmic RNA-binding protein with roles in the regulation of mRNA stability and translation. In this study, we identified a novel function for Unr, which acts as a positive regulator of placental development. Unr expression studies in the developing placenta revealed the presence of Unr-rich foci that are apparently located in the nuclei of trophoblast giant cells (TGCs). We determined that what we initially thought to be foci, were actually cross sections of a network of double-wall nuclear membrane invaginations that contain a cytoplasmic core related to the nucleoplasmic reticulum (NR). We named them, accordingly, Unr-NRs. Unr-NRs constitute a novel type of NR because they contain high levels of poly(A) RNA and translation factors, and are sites of active translation. In murine tissues, Unr-NRs are only found in two polyploid cell types, in TGCs and hepatocytes. In vitro, their formation is linked to stress and polyploidy because, in three cancer cell lines, cytotoxic drugs that are known to promote polyploidization induce their formation. Finally, we show that Unr is required in vivo for the formation of Unr-containing NRs because these structures are absent in Unr-null TGCs.
dc.language.isoENen_US
dc.subject.enCSDE1
dc.subject.enNucleoplasmic reticulum
dc.subject.enPolyploid cells
dc.subject.enUnr
dc.subject.enUnr knockout
dc.subject.enmRNA translation
dc.title.enUnr defines a novel class of nucleoplasmic reticulum involved in mRNA translation
dc.typeArticle de revueen_US
dc.identifier.doi10.1242/jcs.198697en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie du développementen_US
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaireen_US
bordeaux.journalJournal of Cell Scienceen_US
bordeaux.page1796 - 1808en_US
bordeaux.volume130en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue10en_US
bordeaux.institutionCNRSen_US
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-01690511
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cell%20Science&rft.date=2017-05-15&rft.volume=130&rft.issue=10&rft.spage=1796%20-%201808&rft.epage=1796%20-%201808&rft.eissn=0021-9533&rft.issn=0021-9533&rft.au=SALTEL,%20Fr%C3%A9d%C3%A9ric&GIESE,%20Alban&AZZI,%20Lamia&ELATMANI,%20Habiba&COSTET,%20Pierre&rft.genre=article


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