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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

dc.rights.licenseopenen_US
dc.contributor.authorALTMAN, Matthew C.
dc.contributor.authorRINCHAI, Darawan
dc.contributor.authorBALDWIN, Nicole
dc.contributor.authorTOUFIQ, Mohammed
dc.contributor.authorWHALEN, Elizabeth
dc.contributor.authorGARAND, Mathieu
dc.contributor.authorSYED AHAMED KABEER, Basirudeen
dc.contributor.authorALFAKI, Mohamed
dc.contributor.authorPRESNELL, Scott R.
dc.contributor.authorKHAENAM, Prasong
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAYLLON-BENITEZ, Aaron
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOUGIN, Fleur
IDREF: 116242337
hal.structure.identifierLaboratoire Bordelais de Recherche en Informatique [LaBRI]
dc.contributor.authorTHEBAULT, Patricia
dc.contributor.authorCHICHE, Laurent
dc.contributor.authorJOURDE-CHICHE, Noemie
dc.contributor.authorPHILLIPS, J. Theodore
dc.contributor.authorKLINTMALM, Goran
dc.contributor.authorO'GARRA, Anne
dc.contributor.authorBERRY, Matthew
dc.contributor.authorBLOOM, Chloe
dc.contributor.authorWILKINSON, Robert J.
dc.contributor.authorGRAHAM, Christine M.
dc.contributor.authorLIPMAN, Marc
dc.contributor.authorLERTMEMONGKOLCHAI, Ganjana
dc.contributor.authorBEDOGNETTI, Davide
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorKHERADMAND, Farrah
dc.contributor.authorMEJIAS, Asuncion
dc.contributor.authorRAMILO, Octavio
dc.contributor.authorPALUCKA, Karolina
dc.contributor.authorPASCUAL, Virginia
dc.contributor.authorBANCHEREAU, Jacques
dc.contributor.authorCHAUSSABEL, Damien
dc.date.accessioned2023-06-26T14:34:10Z
dc.date.available2023-06-26T14:34:10Z
dc.date.issued2021-07-19
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182835
dc.description.abstractEnAs the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. Here, we describe the development of a new fixed repertoire of transcriptional modules, BloodGen3, that is designed to serve as a stable reusable framework for the analysis and interpretation of blood transcriptome data. The construction of this repertoire is based on co-clustering patterns observed across sixteen immunological and physiological states encompassing 985 blood transcriptome profiles. Interpretation is supported by customized resources, including module-level?analysis workflows, fingerprint grid plot visualizations, interactive web applications and an extensive annotation framework comprising functional profiling reports and reference transcriptional profiles. Taken together, this well-characterized and well-supported transcriptional module repertoire can be employed for the interpretation and benchmarking of blood transcriptome profiles within and across patient cohorts. Blood transcriptome fingerprints for the 16 reference cohorts can be accessed interactively via:? https://drinchai.shinyapps.io/BloodGen3Module/ .
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enDevelopment of a fixed module repertoire for the analysis and interpretation of blood transcriptome data
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-021-24584-wen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34282143en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page4385en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2021-07-19&rft.volume=12&rft.issue=1&rft.spage=4385&rft.epage=4385&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=ALTMAN,%20Matthew%20C.&RINCHAI,%20Darawan&BALDWIN,%20Nicole&TOUFIQ,%20Mohammed&WHALEN,%20Elizabeth&rft.genre=article


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