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CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

dc.rights.licenseopenen_US
dc.contributor.authorLEVY, Yves
dc.contributor.authorWIEDEMANN, Aurelie
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
dc.contributor.authorDURAND, Melany
dc.contributor.authorLEFEBVRE, Cecile
dc.contributor.authorSURENAUD, Mathieu
dc.contributor.authorLACABARATZ, Christine
dc.contributor.authorPERREAU, Matthieu
dc.contributor.authorFOUCAT, Emile
dc.contributor.authorDECHENAUD, Marie
dc.contributor.authorTISSERAND, Pascaline
dc.contributor.authorBLENGIO, Fabiola
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHIVERT, Benjamin
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGAUTHIER, Marine
dc.contributor.authorCERVANTES-GONZALEZ, Minerva
dc.contributor.authorBACHELET, Delphine
dc.contributor.authorLAOUENAN, Cedric
dc.contributor.authorBOUADMA, Lila
dc.contributor.authorTIMSIT, Jean-Francois
dc.contributor.authorYAZDANPANAH, Yazdan
dc.contributor.authorPANTALEO, Giuseppe
dc.contributor.authorHOCINI, Hakim
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.date.accessioned2023-06-26T14:27:27Z
dc.date.available2023-06-26T14:27:27Z
dc.date.issued2021-07-23
dc.identifier.issn2589-0042en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182834
dc.description.abstractEnThe identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Instituteen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enImmunology
dc.subject.enVirology
dc.title.enCD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.isci.2021.102711en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34127958en_US
bordeaux.journaliScienceen_US
bordeaux.page102711en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=iScience&amp;rft.date=2021-07-23&amp;rft.volume=24&amp;rft.issue=7&amp;rft.spage=102711&amp;rft.epage=102711&amp;rft.eissn=2589-0042&amp;rft.issn=2589-0042&amp;rft.au=LEVY,%20Yves&amp;WIEDEMANN,%20Aurelie&amp;HEJBLUM,%20Boris&amp;DURAND,%20Melany&amp;LEFEBVRE,%20Cecile&amp;rft.genre=article


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