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Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

dc.rights.licenseopenen_US
dc.contributor.authorHEMELAAR, Joris
dc.contributor.authorELANGOVAN, Ramyiadarsini
dc.contributor.authorYUN, Jason
dc.contributor.authorDICKSON-TETTEH, Leslie
dc.contributor.authorFLEMINGER, Isabella
dc.contributor.authorKIRTLEY, Shona
dc.contributor.authorWILLIAMS, Brian
dc.contributor.authorWILLIAMS, Eleanor
dc.contributor.authorGHYS, Peter
dc.contributor.authorABIMIKU, Alash'Le
dc.contributor.authorAGWALE, Simon
dc.contributor.authorARCHIBALD, Chris
dc.contributor.authorAVIDOR, Boaz
dc.contributor.authorBARBÁS, María Gabriela
dc.contributor.authorBARRÉ-SINOUSSI, Françoise
dc.contributor.authorBARUGAHARE, Banson
dc.contributor.authorBELABBES, El Hadj
dc.contributor.authorBERTAGNOLIO, Silvia
dc.contributor.authorBIRX, Deborah
dc.contributor.authorBOBKOV, Aleksei
dc.contributor.authorBRANDFUL, James
dc.contributor.authorBREDELL, Helba
dc.contributor.authorBRENNAN, Catherine
dc.contributor.authorBROOKS, James
dc.contributor.authorBRUCKOVA, Marie
dc.contributor.authorBUONAGURO, Luigi
dc.contributor.authorBUONAGURO, Franco
dc.contributor.authorBUTTÒ, Stefano
dc.contributor.authorBUVÉ, Anne
dc.contributor.authorCAMPBELL, Mary
dc.contributor.authorCARR, Jean
dc.contributor.authorCARR, Alex
dc.contributor.authorCARR, Manuel Gómez
dc.contributor.authorCELUM, Connie
dc.contributor.authorCHAPLIN, Beth
dc.contributor.authorCHARLES, Macarthur
dc.contributor.authorCHATZIDIMITRIOU, Dimitrios
dc.contributor.authorCHEN, Zhiwei
dc.contributor.authorCHIJIWA, Katsumi
dc.contributor.authorCOOPER, David
dc.contributor.authorCUNNINGHAM, Philip
dc.contributor.authorDAGNRA, Anoumou
dc.contributor.authorDE GASCUN, Cillian
dc.contributor.authorDEL AMO, Julia
dc.contributor.authorDELGADO, Elena
dc.contributor.authorDIETRICH, Ursula
dc.contributor.authorDWYER, Dominic
dc.contributor.authorELLENBERGER, Dennis
hal.structure.identifierNational AIDS Centre
dc.contributor.authorENSOLI, Barbara
dc.contributor.authorESSEX, Max
dc.contributor.authorGAO, Feng
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorFLEURY, Hervé
dc.contributor.authorFONJUNGO, Peter
dc.contributor.authorFOULONGNE, Vincent
dc.contributor.authorGADKARI, Deepak
dc.contributor.authorGARCIA, Fédérico
dc.contributor.authorGARSIA, Roger
dc.contributor.authorGERSHY-DAMET, Guy Michel
dc.contributor.authorGLYNN, Judith
dc.contributor.authorGOODALL, Ruth
dc.contributor.authorGROSSMAN, Zehava
dc.contributor.authorLINDENMEYER-GUIMARÃES, Monick
dc.contributor.authorHAHN, Beatrice
dc.contributor.authorHAMERS, Raph
dc.contributor.authorHAMOUDA, Osamah
dc.contributor.authorHANDEMA, Ray
dc.contributor.authorHE, Xiang
dc.contributor.authorHE, Joshua
dc.contributor.authorHO, David
dc.contributor.authorHO, Africa
dc.contributor.authorHO, Mina
dc.contributor.authorHUNT, Gillian
dc.contributor.authorITO, Masahiko
dc.contributor.authorBEL HADJ KACEM, Mohamed Ali
dc.contributor.authorKAHLE, Erin
dc.contributor.authorKALEEBU, Pontiano Kaleebu
dc.contributor.authorKALISH, Marcia
dc.contributor.authorKAMARULZAMAN, Adeeba
dc.contributor.authorKANG, Chun
dc.contributor.authorKANKI, Phyllis
dc.contributor.authorKARAMOV, Edward
dc.contributor.authorKARASI, Jean
dc.contributor.authorKAYITENKORE, Kayitesi
dc.contributor.authorKELLEHER, Tony
dc.contributor.authorKITAYAPORN, Dwip
dc.contributor.authorKOSTRIKIS, Leondios
dc.contributor.authorKUCHERER, Claudia
dc.contributor.authorLARA, Claudia
dc.contributor.authorLEITNER, Thomas
dc.contributor.authorLIITSOLA, Kirsi
dc.contributor.authorLINGAPPA, Jai
dc.contributor.authorLINKA, Marek
dc.contributor.authorLORENZANA DE RIVERA, Ivette
dc.contributor.authorLUKASHOV, Vladimir
dc.contributor.authorMAAYAN, Shlomo
dc.contributor.authorMAYR, Luzia
dc.contributor.authorMCCUTCHAN, Francine
dc.contributor.authorMEDA, Nicolas
dc.contributor.authorMENU, Elisabeth
dc.contributor.authorMHALU, Fred
dc.contributor.authorMLOKA, Doreen
dc.contributor.authorMOKILI, John
dc.contributor.authorMONTES, Brigitte
dc.contributor.authorMOR, Orna
dc.contributor.authorMOR, Mariza
dc.contributor.authorMOSHA, Fausta
dc.contributor.authorMOUSSI, Awatef
dc.contributor.authorMULLINS, James
dc.contributor.authorNAJERA, Rafael
dc.contributor.authorNASR, Mejda
dc.contributor.authorNDEMBI, Nicaise
dc.contributor.authorNEILSON, Joel
dc.contributor.authorNERURKAR, Vivek
dc.contributor.authorNEUHANN, Florian
dc.contributor.authorNOLTE, Claudine
dc.contributor.authorNOVITSKY, Vlad
dc.contributor.authorNYAMBI, Philip
dc.contributor.authorOFNER, Marianna
dc.contributor.authorPALADIN, Fem
dc.contributor.authorPAPA, Anna
dc.contributor.authorPAPE, Jean
dc.contributor.authorPARKIN, Neil
dc.contributor.authorPARRY, Chris
dc.contributor.authorPEETERS, Martine
dc.contributor.authorPELLETIER, Alex
dc.contributor.authorPÉREZ-ÁLVAREZ, Lucía
dc.contributor.authorPILLAY, Deenan
dc.contributor.authorPINTO, Angie
dc.contributor.authorQUANG, Trinh Duy
dc.contributor.authorRADEMEYER, Cecilia
dc.contributor.authorRAIKANIKODA, Filimone
dc.contributor.authorRAYFIELD, Ray
dc.contributor.authorREYNES, Jean
dc.contributor.authorRINKE DE WIT, Tobias
dc.contributor.authorROBBINS, Kenneth
dc.contributor.authorMOR, Morgane
dc.contributor.authorROUSSEAU, Chris
dc.contributor.authorSALAZAR-GONZALES, Jesus
dc.contributor.authorSALEM, Hanan
dc.contributor.authorSALMINEN, Mika
dc.contributor.authorHO, Horacio
dc.contributor.authorSANDSTROM, Paul
dc.contributor.authorSANTIAGO, Mario
dc.contributor.authorSARR, Abdoulaye
dc.contributor.authorSCHROEDER, Bryan
dc.contributor.authorSEGONDY, Michel
dc.contributor.authorSELHORST, Philip
dc.contributor.authorSEMPALA, Sylvester
dc.contributor.authorSERVAIS, Jean
dc.contributor.authorSHAIK, Ansari
dc.contributor.authorSHAO, Yiming
hal.structure.identifierLaboratory of Virology
dc.contributor.authorSLIM, Amine
dc.contributor.authorSOARES, Marcelo
dc.contributor.authorSONGOK, Elijah
dc.contributor.authorSTEWART, Debbie
dc.contributor.authorSTOKES, Julie
dc.contributor.authorSUBBARAO, Shambavi
dc.contributor.authorSUTTHENT, Ruengpung
dc.contributor.authorTAKEHISA, Jun
dc.contributor.authorTANURI, Amilcar
dc.contributor.authorTEE, Kok Keng
dc.contributor.authorTHAPA, Kiran
dc.contributor.authorTHOMSON, Michael
dc.contributor.authorTRAN, Tyna
dc.contributor.authorURASSA, Willy
dc.contributor.authorUSHIJIMA, Hiroshi
dc.contributor.authorVAN DE PERRE, Philip
dc.contributor.authorVAN DER GROEN, Guido
dc.contributor.authorVAN LAETHEM, Kristel
dc.contributor.authorVAN OOSTERHOUT, Joep
dc.contributor.authorVAN SIGHEM, Ard
dc.contributor.authorVAN WIJNGAERDEN, Eric
dc.contributor.authorVANDAMME, Anne
dc.contributor.authorVERCAUTEREN, Jurgen
dc.contributor.authorVIDAL, Nicole
dc.contributor.authorWALLACE, Lesley
dc.contributor.authorWILLIAMS, Carolyn
dc.contributor.authorWOLDAY, Dawit
dc.contributor.authorXU, Jianqing
dc.contributor.authorYANG, Chun
dc.contributor.authorZHANG, Linqi
dc.contributor.authorZHANG, Rong
dc.date.accessioned2023-06-26T10:35:29Z
dc.date.available2023-06-26T10:35:29Z
dc.date.issued2018-11
dc.identifier.issn1473-3099en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182823
dc.description.abstractEnGlobal genetic diversity of HIV-1 is a major challenge to the development of HIV vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and recombinants during 1990–2015.We searched PubMed, EMBASE (Ovid), CINAHL (Ebscohost), and Global Health (Ovid) for HIV-1 subtyping studies published between Jan 1, 1990, and Dec 31, 2015. We collected additional unpublished HIV-1 subtyping data through a global survey. We included prevalence studies with HIV-1 subtyping data collected during 1990–2015. We grouped countries into 14 regions and analysed data for four time periods (1990–99, 2000–04, 2005–09, and 2010–15). The distribution of HIV-1 subtypes, circulating recombinant forms (CRFs), and unique recombinant forms (URFs) in individual countries was weighted according to the UNAIDS estimates of the number of people living with HIV (PLHIV) in each country to generate regional and global estimates of HIV-1 diversity in each time period. The primary outcome was the number of samples designated as HIV-1 subtypes A, B, C, D, F, G, H, J, K, CRFs, and URFs. The systematic review is registered with PROSPERO, number CRD42017067164.This systematic review and global survey yielded 2203 datasets with 383 519 samples from 116 countries in 1990–2015. Globally, subtype C accounted for 46·6% (16 280 897/34 921 639 of PLHIV) of all HIV-1 infections in 2010–15. Subtype B was responsible for 12·1% (4 235 299/34 921 639) of infections, followed by subtype A (10·3%; 3 587 003/34 921 639), CRF02_AG (7·7%; 2 705 110/34 921 639), CRF01_AE (5·3%; 1 840 982/34 921 639), subtype G (4·6%; 1 591 276/34 921 639), and subtype D (2·7%; 926 255/34 921 639). Subtypes F, H, J, and K combined accounted for 0·9% (311 332/34 921 639) of infections. Other CRFs accounted for 3·7% (1 309 082/34 921 639), bringing the proportion of all CRFs to 16·7% (5 844 113/34 921 639). URFs constituted 6·1% (2 134 405/34 921 639), resulting in recombinants accounting for 22·8% (7 978 517/34 921 639) of all global HIV-1 infections. The distribution of HIV-1 subtypes and recombinants changed over time in countries, regions, and globally. At a global level during 2005–15, subtype B increased, subtypes A and D were stable, and subtypes C and G and CRF02_AG decreased. CRF01_AE, other CRFs, and URFs increased, leading to a consistent increase in the global proportion of recombinants over time.Global and regional HIV diversity is complex and evolving, and is a major challenge to HIV vaccine development. Surveillance of the global molecular epidemiology of HIV-1 remains crucial for the design, testing, and implementation of HIV vaccines.
dc.language.isoENen_US
dc.title.enGlobal and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/S1473-3099(18)30647-9en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalThe Lancet Infectious Diseasesen_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-01957321
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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