Whispers of change in preschool asthma phenotypes: Findings in the French ELFE cohort
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KHAN, Sadia | |
| dc.contributor.author | OUAALAYA, El Hassane | |
| dc.contributor.author | CHAUVEAU, Amandine Divaret | |
| dc.contributor.author | SCHERER, Emeline | |
| dc.contributor.author | REBOUX, Gabriel | |
| dc.contributor.author | MILLON, Laurence | |
| dc.contributor.author | DESCHILDRE, Antoine | |
| dc.contributor.author | MARGUET, Christophe | |
| dc.contributor.author | DUFOURG, Marie-Noëlle | |
| dc.contributor.author | CHARLES, Marie-Aline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RAHERISON-SEMJEN, Chantal | |
| dc.date.accessioned | 2023-06-26T07:41:02Z | |
| dc.date.available | 2023-06-26T07:41:02Z | |
| dc.date.issued | 2023-05-22 | |
| dc.identifier.issn | 1532-3064 (Electronic) 0954-6111 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182809 | |
| dc.description.abstractEn | RATIONALE: Early life asthma phenotyping remains an unmet need in pediatric asthma. In France, severe pediatric asthma phenotyping has been done extensively; however, phenotypes in the general population remain underexplored. Based on the course and severity of respiratory/allergic symptoms, we aimed to identify and characterize early life wheeze profiles and asthma phenotypes in the general population. METHODS: ELFE is a general population based birth cohort; which recruited 18,329 newborns in 2011, from 320 maternity units nationwide. Data was collected using parental responses to modified versions of ISAAC questionnaire on eczema, rhinitis, food allergy, cough, wheezing, dyspnoea and sleep disturbance due to wheezing at 3 time points: post-natal (2 months), infancy (age 1) and pre-school (age 5). We built a supervised trajectory for wheeze profiles and an unsupervised approach was used for asthma phenotypes. Chi squared (χ2) test or fisher's exact test was used as appropriate (p < 0.05). RESULTS: Wheeze profiles and asthma phenotypes were ascertained at age 5. Supervised wheeze trajectory of 9161 children resulted in 4 wheeze profiles: Persistent (0.8%), Transient (12.1%), Incident wheezers at age 5 (13.3%) and Non wheezers (73.9%). While 9517 children in unsupervised clusters displayed 4 distinct asthma phenotypes: Mildly symptomatic (70%), Post-natal bronchiolitis with persistent rhinitis (10.2%), Severe early asthma (16.9%) and Early persistent atopy with late onset severe wheeze (2.9%). CONCLUSION: We successfully determined early life wheeze profiles and asthma phenotypes in the general population of France. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Asthma in early life | |
| dc.subject.en | Asthma epidemiology | |
| dc.subject.en | Asthma (clinical aspects) | |
| dc.subject.en | Asthma severity | |
| dc.subject.en | Wheezing | |
| dc.subject.en | Cluster analysis | |
| dc.title.en | Whispers of change in preschool asthma phenotypes: Findings in the French ELFE cohort | |
| dc.title.alternative | Respir Med | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.rmed.2023.107263 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37224890 | en_US |
| bordeaux.journal | Respiratory Medicine | en_US |
| bordeaux.page | 107263 | en_US |
| bordeaux.volume | 215 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04140780 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-06-26T07:41:08Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Respiratory%20Medicine&rft.date=2023-05-22&rft.volume=215&rft.spage=107263&rft.epage=107263&rft.eissn=1532-3064%20(Electronic)%200954-6111%20(Linking)&rft.issn=1532-3064%20(Electronic)%200954-6111%20(Linking)&rft.au=KHAN,%20Sadia&OUAALAYA,%20El%20Hassane&CHAUVEAU,%20Amandine%20Divaret&SCHERER,%20Emeline&REBOUX,%20Gabriel&rft.genre=article |
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