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Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

dc.rights.licenseopenen_US
dc.contributor.authorADLAM, David
dc.contributor.authorBERRANDOU, Takiy-Eddine
dc.contributor.authorGEORGES, Adrien
dc.contributor.authorNELSON, Christopher P.
dc.contributor.authorGIANNOULATOU, Eleni
dc.contributor.authorHENRY, Josephine
dc.contributor.authorMA, Lijiang
dc.contributor.authorBLENCOWE, Montgomery
dc.contributor.authorTURLEY, Tamiel N.
dc.contributor.authorYANG, Min-Lee
dc.contributor.authorCHOPADE, Sandesh
dc.contributor.authorFINAN, Chris
dc.contributor.authorBRAUND, Peter S.
dc.contributor.authorSADEG-SAYOUD, Ines
dc.contributor.authorIISMAA, Siiri E.
dc.contributor.authorKOSEL, Matthew L.
dc.contributor.authorZHOU, Xiang
dc.contributor.authorHAMBY, Stephen E.
dc.contributor.authorCHENG, Jenny
dc.contributor.authorLIU, Lu
dc.contributor.authorTARR, Ingrid
dc.contributor.authorMULLER, David W. M.
dc.contributor.authorD'ESCAMARD, Valentina
dc.contributor.authorKING, Annette
dc.contributor.authorBRUNHAM, Liam R.
dc.contributor.authorBARANOWSKA-CLARKE, Ania A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorOLIN, Jeffrey W.
dc.contributor.authorPATIL, Snehal
dc.contributor.authorHESSELSON, Stephanie E.
dc.contributor.authorJUNDAY, Keerat
dc.contributor.authorKANONI, Stavroula
dc.contributor.authorARAGAM, Krishna G.
dc.contributor.authorBUTTERWORTH, Adam S.
dc.contributor.authorTWEET, Marysia S.
dc.contributor.authorGULATI, Rajiv
dc.contributor.authorCOMBARET, Nicolas
dc.contributor.authorKADIAN-DODOV, Daniella
dc.contributor.authorKALMAN, Jonathan M.
dc.contributor.authorFATKIN, Diane
dc.contributor.authorHINGORANI, Aroon D.
dc.contributor.authorSAW, Jacqueline
dc.contributor.authorWEBB, Tom R.
dc.contributor.authorHAYES, Sharonne N.
dc.contributor.authorYANG, Xia
dc.contributor.authorGANESH, Santhi K.
dc.contributor.authorOLSON, Timothy M.
dc.contributor.authorKOVACIC, Jason C.
dc.contributor.authorGRAHAM, Robert M.
dc.contributor.authorSAMANI, Nilesh J.
dc.contributor.authorBOUATIA-NAJI, Nabila
dc.date.accessioned2023-06-23T09:10:24Z
dc.date.available2023-06-23T09:10:24Z
dc.date.issued2023-05-29
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182777
dc.description.abstractEnSpontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enGenome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-023-01410-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37248441en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page964-972en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04138736
hal.version1
hal.date.transferred2023-06-23T09:11:13Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Genetics&rft.date=2023-05-29&rft.volume=55&rft.spage=964-972&rft.epage=964-972&rft.eissn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.issn=1546-1718%20(Electronic)%201061-4036%20(Linking)&rft.au=ADLAM,%20David&BERRANDOU,%20Takiy-Eddine&GEORGES,%20Adrien&NELSON,%20Christopher%20P.&GIANNOULATOU,%20Eleni&rft.genre=article


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