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Association of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium

dc.rights.licenseopenen_US
dc.contributor.authorVERGROESEN, Joelle E.
dc.contributor.authorSCHUSTER, Alexander K.
dc.contributor.authorSTUART, Kelsey V.
dc.contributor.authorASEFA, Nigus G
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cécile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHWEITZER, Cedric
dc.contributor.authorBARRETO, Patricia
dc.contributor.authorCOIMBRA, Rita
dc.contributor.authorFOSTER, Paul J.
dc.contributor.authorLUBEN, Robert N.
dc.contributor.authorPFEIFFER, Norbert
dc.contributor.authorSTINGL, Julia V.
dc.contributor.authorKIRSTEN, Toralf
dc.contributor.authorRAUSCHER, Franziska G.
dc.contributor.authorWIRKNER, Kerstin
dc.contributor.authorJANSONIUS, Nomdo M.
dc.contributor.authorARNOULD, Louis
dc.contributor.authorCREUZOT-GARCHER, Catherine P.
dc.contributor.authorSTRICKER, Bruno H.
dc.contributor.authorKESKINI, Christina
dc.contributor.authorTOPOUZIS, Fotis
dc.contributor.authorBERTELSEN, Geir
dc.contributor.authorEGGEN, Anne E.
dc.contributor.authorBIKBOV, Mukharram M.
dc.contributor.authorJONAS, Jost B.
dc.contributor.authorKLAVER, Caroline C. W.
dc.contributor.authorRAMDAS, Wishal D.
dc.contributor.authorKHAWAJA, Anthony P.
dc.date.accessioned2023-06-21T09:35:23Z
dc.date.available2023-06-21T09:35:23Z
dc.date.issued2023-05-05
dc.identifier.issn1549-4713 (Electronic) 0161-6420 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182732
dc.description.abstractEnPURPOSE: To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. DESIGN: Meta-analysis of eleven population-based cohort studies of the European Eye Epidemiology (E3) consortium. PARTICIPANTS: A total of 143240 participants were included in the glaucoma analyses and 47177 participants in the IOP analyses. METHODS: We examined associations of four categories of systemic medications (antihypertensive medications: beta-blockers, diuretics, calcium channel blockers [CCBs], alpha-agonists, angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers; lipid-lowering medications; antidepressants; antidiabetic medications) with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Multivariable regression analyses were carried out in each study and results were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in diabetic participants only. MAIN OUTCOME MEASURES: Glaucoma prevalence and IOP. RESULTS: In the meta-analyses of our maximally-adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR] with corresponding 95% confidence interval [95% CI]: 1.23 [1.08 to 1.39]). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR [95% CI]: 1.96 [1.23 to 3.12]). The use of other antihypertensive medications, lipid-lowering medications, antidepressants or antidiabetic medications were not clearly associated with glaucoma. Use of systemic beta-blockers was associated with a lower IOP (Beta [95% CI]: -0.33 [-0.57 to -0.08] mmHg). Monotherapy of both selective (Beta [95% CI]: -0.45 [-0.74 to -0.16] mmHg) and non-selective (Beta [95% CI]: -0.54 [-0.94 to -0.15] mmHg) systemic beta-blockers was associated with lower IOP. There was a suggestive association between use of high-ceiling diuretics and lower IOP (Beta [95% CI]: -0.30 [-0.47; -0.14] mmHg), but not when used as monotherapy. Use of other antihypertensive medications, lipid-lowering medications, antidepressants, or antidiabetic medications were not associated with IOP. CONCLUSIONS: We identified a potentially harmful association between use of CCBs and glaucoma prevalence. Additionally, we observed and quantified the association of lower IOP with systemic beta-blocker use. Both findings are potentially important given that glaucoma patients frequently use systemic antihypertensive medications. Determining whether the CCB association is causal should be a research priority.
dc.description.sponsorship/en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enEpidemiology
dc.subject.enGlaucoma
dc.subject.enIntraocular pressure
dc.subject.enSystemic medication
dc.title.enAssociation of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium
dc.title.alternativeOphthalmologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ophtha.2023.05.001en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37150298en_US
bordeaux.journalOphthalmology: Journal of The American Academy of Ophthalmologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ophthalmology:%20Journal%20of%20The%20American%20Academy%20of%20Ophthalmology&rft.date=2023-05-05&rft.eissn=1549-4713%20(Electronic)%200161-6420%20(Linking)&rft.issn=1549-4713%20(Electronic)%200161-6420%20(Linking)&rft.au=VERGROESEN,%20Joelle%20E.&SCHUSTER,%20Alexander%20K.&STUART,%20Kelsey%20V.&ASEFA,%20Nigus%20G&COUGNARD-GREGOIRE,%20Audrey&rft.genre=article


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