Role of endocannabinoids in energy-balance regulation in participants in the postobese state - A PREVIEW study
| dc.rights.license | open | en_US |
| dc.contributor.author | DRUMMEN, Mathijs | |
| dc.contributor.author | TISCHMANN, Lea | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GATTA-CHERIFI, Blandine | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MATIAS, Isabelle | |
| hal.structure.identifier | University of Copenhagen | |
| dc.contributor.author | RABEN, Anne | |
| dc.contributor.author | ADAM, Tanja | |
| dc.contributor.author | WESTERTERP-PLANTENGA, Margriet S. | |
| dc.date.accessioned | 2023-06-19T08:47:40Z | |
| dc.date.available | 2023-06-19T08:47:40Z | |
| dc.date.issued | 2020-07-01 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182715 | |
| dc.description.abstractEn | Context: Endocannabinoids are suggested to play a role in energy balance regulation. Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes. Design and Participants: Participants (n = 38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber. Main Outcome Measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed. Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to body mass index (AEA) or body fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. Area under the curve (AUC) of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body fat% (P < .05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs the MP group. Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, whereas the endocannabinoid AEA and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure during the day. © 2020 Endocrine Society. All rights reserved. | |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Endocannabinoids | |
| dc.subject.en | Energy balance | |
| dc.subject.en | Adiposity | |
| dc.subject.en | Protein | |
| dc.title.en | Role of endocannabinoids in energy-balance regulation in participants in the postobese state - A PREVIEW study | |
| dc.title.alternative | J Clin Endocrinol Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1210/clinem/dgaa193 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32333763 | en_US |
| dc.description.sponsorshipEurope | EU Framework Programme Horizon 2020 | en_US |
| bordeaux.journal | Journal of Clinical Endocrinology and Metabolism | en_US |
| bordeaux.volume | 105 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04132470 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-06-19T08:47:49Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Endocrinology%20and%20Metabolism&rft.date=2020-07-01&rft.volume=105&rft.issue=7&rft.au=DRUMMEN,%20Mathijs&TISCHMANN,%20Lea&GATTA-CHERIFI,%20Blandine&COTA,%20Daniela&MATIAS,%20Isabelle&rft.genre=article |
