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dc.rights.licenseopenen_US
hal.structure.identifierIcahn School of Medicine at Mount Sinai [New York] [MSSM]
dc.contributor.authorOSSIPOVA, Olga
hal.structure.identifierIcahn School of Medicine at Mount Sinai [New York] [MSSM]
dc.contributor.authorITOH, Keiji
hal.structure.identifierIcahn School of Medicine at Mount Sinai [New York] [MSSM]
dc.contributor.authorRADU, Aurelian
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorEZAN, Jerome
hal.structure.identifierIcahn School of Medicine at Mount Sinai [New York] [MSSM]
dc.contributor.authorSOKOL, Sergei Y.
dc.date.accessioned2023-06-15T14:13:26Z
dc.date.available2023-06-15T14:13:26Z
dc.date.issued2020-09-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182698
dc.description.abstractEnAmong the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt families. No new classes of extracellular mesoderm-inducing factors have been identified in more than two decades. Here, we show that the pinhead (pnhd) gene encodes a secreted protein that is essential for the activation of a subset of mesodermal markers in the Xenopus embryo. RNA sequencing revealed that many transcriptional targets of Pnhd are shared with those of the FGF pathway. Pnhd activity was accompanied by Erk phosphorylation and required FGF and Nodal but not Wnt signaling. We propose that during gastrulation Pnhd acts in the marginal zone to contribute to mesoderm heterogeneity via an FGF receptor-dependent positive feedback mechanism. © 2020. Published by The Company of Biologists Ltd
dc.language.isoENen_US
dc.subject.enWnt
dc.subject.enFGF
dc.subject.enErk1
dc.subject.enAkt
dc.subject.enBrachyury
dc.subject.enNodal
dc.subject.enAntero-posterior axis
dc.subject.enXenopus
dc.title.enPinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway
dc.title.alternativeDevelopmenten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1242/dev.188094en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32859582en_US
bordeaux.journalDevelopment (Cambridge)en_US
bordeaux.volume147en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue17en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPolarité planaire et plasticitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEunice Kennedy Shriver National Institute of Child Health and Human Developmenten_US
hal.identifierhal-04129947
hal.version1
hal.date.transferred2023-06-15T14:13:50Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Development%20(Cambridge)&rft.date=2020-09-11&rft.volume=147&rft.issue=17&rft.au=OSSIPOVA,%20Olga&ITOH,%20Keiji&RADU,%20Aurelian&EZAN,%20Jerome&SOKOL,%20Sergei%20Y.&rft.genre=article


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