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(De)glutamylation and cell death in Leishmania parasites

dc.rights.licenseopenen_US
dc.contributor.authorBASMACIYAN, Louise
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorROBINSON, Derrick
dc.contributor.authorAZAS, Nadine
dc.contributor.authorCASANOVA, Magali
dc.date.accessioned2023-06-14T09:32:24Z
dc.date.available2023-06-14T09:32:24Z
dc.date.issued2019-04-24
dc.identifier.issn1935-2727en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182674
dc.description.abstractEnTrypanosomatids are flagellated protozoan parasites that are very unusual in terms of cyto-skeleton organization but also in terms of cell death. Most of the Trypanosomatid cytoskele-ton consists of microtubules, forming different substructures including a subpellicular corset. Oddly, the actin network appears structurally and functionally different from other eukaryotic actins. And Trypanosomatids have an apoptotic phenotype under cell death conditions, but the pathways involved are devoid of key mammal proteins such as caspases or death receptors, and the triggers involved in apoptotic induction remain unknown. In this article, we have studied the role of the post-translational modifications, deglutamylation and poly-glutamylation, in Leishmania. We have shown that Leishmania apoptosis was linked to poly-glutamylation and hypothesized that the cell survival process autophagy was linked to deglutamylation. A balance seems to be established between polyglutamylation and deglu-tamylation, with imbalance inducing microtubule or other protein modifications characterizing either cell death if polyglutamylation was prioritized, or the cell survival process of autophagy if deglutamylation was prioritized. This emphasizes the role of post-translational modifications in cell biology, inducing cell death or cell survival of infectious agents.
dc.description.sponsorshipI.H.U. Méditerranée Infection - ANR-10-IAHU-0003en_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enApoptosis
dc.subject.enLeishmania
dc.subject.enAutophagic cell death
dc.subject.enHyperexpression techniques
dc.subject.enMicrotubules
dc.subject.enCytoskeleton
dc.subject.enFlagella
dc.subject.enTubulins
dc.title.en(De)glutamylation and cell death in Leishmania parasites
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pntd.0007264en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologieen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologieen_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologieen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaireen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentesen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
bordeaux.journalPLoS Neglected Tropical Diseasesen_US
bordeaux.pagee0007264en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue4en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02263752
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20Neglected%20Tropical%20Diseases&rft.date=2019-04-24&rft.volume=13&rft.issue=4&rft.spage=e0007264&rft.epage=e0007264&rft.eissn=1935-2727&rft.issn=1935-2727&rft.au=BASMACIYAN,%20Louise&ROBINSON,%20Derrick&AZAS,%20Nadine&CASANOVA,%20Magali&rft.genre=article


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