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The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neurons

dc.rights.licenseopenen_US
dc.contributor.authorMONTALBAN, Enrica
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorWALLE, Roman
dc.contributor.authorCASTEL, Julien
dc.contributor.authorANSOULT, Anthony
dc.contributor.authorHASSOUNA, Rim
dc.contributor.authorFOPPEN, Ewout
dc.contributor.authorFANG, Xi
dc.contributor.authorHUTELIN, Zach
dc.contributor.authorMICKUS, Sophie
dc.contributor.authorPERSZYK, Emily
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPETITBON, Anna
dc.contributor.authorBERTHELET, Jeremy
dc.contributor.authorRODRIGUES-LIMA, Fernando
dc.contributor.authorCEBRIAN-SERRANO, Alberto
dc.contributor.authorGANGAROSSA, Giuseppe
dc.contributor.authorMARTIN, Claire
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorTRIFILIEFF, Pierre
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X
IDREF: 156530244
dc.contributor.authorSMALL, Dana
dc.contributor.authorLUQUET, Serge
dc.date.accessioned2023-06-05T09:24:49Z
dc.date.available2023-06-05T09:24:49Z
dc.date.issued2022-11-01
dc.identifier.issn0006-3223en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182477
dc.description.abstractEnAbstract Significant evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the Taq1A polymorphism is one of the most commonly studied in psychiatry. TaqIA is located in the gene that codes for the Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) near the dopamine D2 dopamine receptor (DR2) gene. Depending on race it affects 30 to 80% of the population and its homozygous expression of the A1 allele correlates with a 30 to 40% reduction of striatal DR2, a typical feature of addiction, over-eating and other psychiatric pathologies. The mechanisms by which the variant influences dopamine signaling and behavior is unknown. Here we used transgenic and viral-mediated strategies to reveal the role of ANKK1 in the regulation of activity and functions of the striatum. We found that Ankk1 is preferentially enriched in striatal DR2 expressing neurons and that Ankk1 loss-of-function in dorsal and ventral striatum leads to alteration in learning, impulsive, and flexible behaviors resembling the endophenotypes described in A1 carriers. We also observed an unsuspected role of ANKK1 in striatal DR2-expressing neurons in the ventral striatum in the regulation of energy homeostasis and documented differential nutrient partitioning in humans with versus without the A1 allele. Overall, our data demonstrate that the Ankk1 gene is necessary for the integrity of striatal functions and reveal a new role for ANKK1 in the regulation of body metabolism.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enD2R receptor
dc.subject.enDopamine signaling
dc.subject.enEating disorders
dc.subject.enGenetic polymorphism
dc.subject.enMetabolism
dc.subject.enReward-associated behavior
dc.title.enThe addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neurons
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biopsych.2023.02.010en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36805080en_US
bordeaux.journalBiological Psychiatryen_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04116977
hal.version1
hal.date.transferred2023-06-05T09:24:54Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological%20Psychiatry&rft.date=2022-11-01&rft.eissn=0006-3223&rft.issn=0006-3223&rft.au=MONTALBAN,%20Enrica&WALLE,%20Roman&CASTEL,%20Julien&ANSOULT,%20Anthony&HASSOUNA,%20Rim&rft.genre=article


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