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Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

dc.rights.licenseopenen_US
dc.contributor.authorLENGVENYTE, Aiste
dc.contributor.authorSTRUMILA, Robertas
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorROUX, Paul
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorWALTER, Michel
dc.contributor.authorD'AMATO, Thierry
dc.contributor.authorJANUEL, Dominique
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorETAIN, Bruno
dc.contributor.authorNAVICKAS, Alvydas
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorCOURTET, Philippe
dc.date.accessioned2023-06-02T13:02:08Z
dc.date.available2023-06-02T13:02:08Z
dc.date.issued2023-02-01
dc.identifier.issn0889-1591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182449
dc.description.abstractEnEvidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based on literature and data-driven principal component analysis. We found that the counts of all blood cell types were only marginally associated with depression severity. Conversely, white blood cell count was significantly associated with the sickness dimension and its four components (anhedonia, slowing down, fatigue, and appetite loss). Platelet count was associated with the insomnia/restlessness dimension and its components (initial, middle, late insomnia and restlessness). Principal component analyses corroborated these results. Platelet count was also associated with suicidal ideation. In analyses stratified by sex, the white blood cell count-sickness dimension association remained significant only in men, and the platelet count-insomnia/restlessness dimension association only in women. Without implying causation, these results suggest that peripheral blood cell counts might be associated with different depressive symptoms in individuals with bipolar disorder, and that white blood cells might be implicated in sickness symptoms and platelets in insomnia/agitation and suicidal ideation.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enBipolar disorder
dc.subject.enBlood cells
dc.subject.enDepression
dc.subject.enHeterogeneity
dc.subject.enInflammation
dc.title.enAssociations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort
dc.title.alternativeBrain, Behavior, and Immunityen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2022.12.002en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36494046en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page176-187en_US
bordeaux.volume108en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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