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Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy
dc.rights.license | open | en_US |
dc.contributor.author | COUFFIGNAL, Camille | |
dc.contributor.author | KOLTA, Sami | |
dc.contributor.author | FLAMANT, Martin | |
hal.structure.identifier | Service des Maladies Infectieuses et Tropicales A [Bordeaux] | |
dc.contributor.author | CAZANAVE, Charles | |
dc.contributor.author | HAYMANN, Jean-Philippe | |
dc.contributor.author | MENTRE, France | |
dc.contributor.author | DUVAL, Xavier | |
dc.contributor.author | LEPORT, Catherine | |
dc.contributor.author | RAFFI, Francois | |
dc.contributor.author | CHÊNE, G. | |
dc.contributor.author | SALAMON, R. | |
dc.contributor.author | MOATTI, J. | |
dc.contributor.author | PIERRET, J. | |
dc.contributor.author | SPIRE, B. | |
dc.contributor.author | BRUN-VÉZINET, F. | |
dc.contributor.author | FLEURY, H. | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
dc.contributor.author | MASQUELIER, B. | |
dc.contributor.author | PEYTAVIN, G. | |
dc.contributor.author | GARRAFFO, R. | |
dc.contributor.author | COSTAGLIOLA, D. | |
dc.contributor.author | DELLAMONICA, P. | |
dc.contributor.author | KATLAMA, C. | |
dc.contributor.author | MEYER, L. | |
dc.contributor.author | SALMON, D. | |
dc.contributor.author | CUZIN, L. | |
hal.structure.identifier | CHU Bordeaux | |
dc.contributor.author | DUPON, M. | |
dc.contributor.author | LE MOING, V. | |
dc.contributor.author | MARCHOU, B. | |
dc.contributor.author | MAY, T. | |
dc.contributor.author | MORLAT, P. | |
dc.contributor.author | RABAUD, C. | |
dc.contributor.author | WALDNER-COMBERNOUX, A. | |
dc.contributor.author | HARDEL, L. | |
dc.contributor.author | REBOUD, P. | |
dc.contributor.author | COUFFIN-CADIERGUES, S. | |
dc.contributor.author | MARCHAND, L. | |
dc.contributor.author | ASSUIED, A. | |
dc.contributor.author | CARRIERI, P. | |
dc.contributor.author | HABAK, S. | |
dc.contributor.author | COUTURIER, F. | |
dc.contributor.author | JADAND, C. | |
dc.contributor.author | PERRIER, A. | |
dc.contributor.author | PRÉAU, M. | |
dc.contributor.author | PROTOPOPESCU, C. | |
dc.contributor.author | SCHMIT, J.L. | |
dc.contributor.author | CHENNEBAULT, J.M. | |
dc.contributor.author | FALLER, J.P. | |
dc.contributor.author | MAGY-BERTRAND, N. | |
dc.contributor.author | CHIROUZE, C. | |
dc.contributor.author | HUMBERT, P. | |
dc.contributor.author | NEAU, D. | |
dc.contributor.author | GRANIER, P. | |
dc.contributor.author | ANSART, S. | |
dc.contributor.author | VERDON, R. | |
dc.contributor.author | MERRIEN, D. | |
dc.contributor.author | CHEVOJON, P. | |
dc.contributor.author | SOBEL, A. | |
dc.contributor.author | LEVY, Y. | |
dc.contributor.author | PIROTH, L. | |
dc.contributor.author | PERRONNE, C. | |
dc.contributor.author | FROGUEL, E. | |
dc.contributor.author | CECCALDI, J. | |
dc.contributor.author | CHIDIAC, C. | |
dc.contributor.author | GRÉGOIRE, V. | |
dc.contributor.author | REYNES, J. | |
dc.contributor.author | FUZIBET, J. | |
dc.contributor.author | ARSAC, P. | |
dc.contributor.author | BOUVET, E. | |
dc.contributor.author | BRICAIRE, F. | |
dc.contributor.author | MONSONEGO, J. | |
dc.contributor.author | GIRARD, P.M. | |
dc.contributor.author | GUILLEVIN, L. | |
dc.contributor.author | HERSON, S. | |
dc.contributor.author | MOLINA, J.M. | |
dc.contributor.author | PIALOUX, G. | |
dc.contributor.author | SAIN, O. | |
dc.contributor.author | SELLIER, P. | |
dc.contributor.author | ROBLOT, F. | |
dc.contributor.author | BANI-SADR, F. | |
dc.contributor.author | MICHELET, C. | |
dc.contributor.author | LUCHT, F. | |
dc.contributor.author | DEBORD, C. | |
dc.contributor.author | MARTIN, T. | |
dc.contributor.author | DE JAUREGUIBERRY, J.P. | |
dc.contributor.author | BERNARD, L. | |
dc.date.accessioned | 2023-06-01T16:05:38Z | |
dc.date.available | 2023-06-01T16:05:38Z | |
dc.date.issued | 2020-02-24 | |
dc.identifier.issn | 0889-2229 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182406 | |
dc.description.abstractEn | We assessed bone mineral density (BMD) in a cohort of human immunodeficiency virus (HIV)-positive patients after a median of 11 years of combination antiretroviral therapy (cART) and evaluated the respective role of HIV infection and antiretroviral drugs (ARVs). A cross-sectional study of 162 participants (131 male) from the ANRS-C08 cohort was performed with bone dual-energy X-ray absorptiometry (DXA) scans and renal assessment. The window of exposure to ARVs was defined as an exposure of more than six cumulative months during the last 3 years before the DXA evaluation to account for a cumulative exposure that could affect bone remodeling. The association with low BMD (Z-score < -2) was assessed by a multiple logistic regression model. The study population was 50 years (median), hepatitis C virus (HCV) (18%), and hepatitis B virus (HBV) (8%) coinfection with HIV-RNA <50 c/mL in 89%, median CD4 of 619/mm3. Prevalence of low BMD was 18% in males and 6% in females. The factors associated with a Z-score < -2 in males were uric acid renal loss [adjusted odds ratio (aOR): 6.1; 95% confidence interval (CI): 1.2-31.5; p = .03], HCV coinfection (aOR: 4.0; 95% CI: 1.3-12.2; p = .02), and less frequent window of exposure to nevirapine (NVP) (aOR: 0.1; 95% CI: 0.02-0.6; p = .01). For the full study sample, there was a strong positive association between duration of exposure to NVP and lumbar spine Z-score (p = .004). HIV-positive patients exposed to long-term cART have a high incidence of low BMD. Tenofovir disoproxil fumarate and ritonavir-boosted protease inhibitors did not seem to be associated with increased risk of low BMD, whereas NVP exposure appeared to have an independent positive association. | |
dc.language.iso | EN | en_US |
dc.subject.en | HIV | |
dc.subject.en | bone mineral density | |
dc.subject.en | nevirapine | |
dc.title.en | Nevirapine Use Is Associated with Higher Bone Mineral Density in HIV-1 Positive Subjects on Long-Term Antiretroviral Therapy | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1089/AID.2019.0229 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
bordeaux.journal | AIDS Research and Human Retroviruses | en_US |
bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | hal-02548927 | |
hal.version | 1 | |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS%20Research%20and%20Human%20Retroviruses&rft.date=2020-02-24&rft.eissn=0889-2229&rft.issn=0889-2229&rft.au=COUFFIGNAL,%20Camille&KOLTA,%20Sami&FLAMANT,%20Martin&CAZANAVE,%20Charles&HAYMANN,%20Jean-Philippe&rft.genre=article |
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