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Exogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multi-centre study (DYNAPYO study)

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOPPRY, Maider
hal.structure.identifierCHU Bordeaux
dc.contributor.authorLEROYER, Camille
hal.structure.identifierCHU Bordeaux
dc.contributor.authorSALY, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVENIER, Anne Gaëlle
dc.contributor.authorSLEKOVEC, Celine
hal.structure.identifierLaboratoire Chrono-environnement (UMR 6249) [LCE]
dc.contributor.authorBERTRAND, Xavier
dc.contributor.authorPARER, Sylvie
dc.contributor.authorALFANDARI, Serge
dc.contributor.authorCAMBAU, Emmanuelle
dc.contributor.authorMÉGARBANE, Bruno
dc.contributor.authorLAWRENCE, Christine
dc.contributor.authorCLAIR, Bernard
dc.contributor.authorLEPAPE, Alain
dc.contributor.authorCASSIER, Pierre
dc.contributor.authorTRIVIER, Dominique
hal.structure.identifierCHU Bordeaux
dc.contributor.authorBOYER, Alexandre
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorBOULESTREAU, Hélène
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorASSELINEAU, Julien
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorDUBOIS, Veronique
hal.structure.identifierEpidémiologie et Biostatistique [Bordeaux]
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
dc.contributor.authorTHIÉBAUT, Rodolphe
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorROGUES, Anne Marie
dc.date.accessioned2023-05-31T14:08:00Z
dc.date.available2023-05-31T14:08:00Z
dc.date.issued2020-01
dc.identifier.issn0195-6701en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182390
dc.description.abstractEnBackground: Pseudomonas aeruginosa remains one of the most common nosocomial pathogens in intensive care units (ICUs). Although exogenous acquisition has been widely documented in outbreaks, its importance is unclear in non-epidemic situations.Aim: To elucidate the role of exogenous origin of P. aeruginosa in ICU patients.Methods: A chronological analysis of the acquisition of P. aeruginosa was performed using samples collected in 2009 in the DYNAPYO cohort study, during which patients and tap water were screened weekly. Molecular relatedness of P. aeruginosa isolates was investigated by pulsed-field gel electrophoresis. Exogenous acquisition was defined as identification of a P. aeruginosa pulsotype previously isolated from another patient or tap water in the ICU.Findings: The DYNAPYO cohort included 1808 patients (10,402 samples) and 233 water taps (4946 samples). Typing of 1515 isolates from 373 patients and 375 isolates from 81 tap water samples identified 296 pulsotypes. Analysis showed exogenous acquisition in 170 (45.6%) of 373 patients. The pulsotype identified had previously been isolated from another patient and from a tap water sample for 86 and 29 patients, respectively. The results differed according to the ICU.Conclusion: Exogenous acquisition of P. aeruginosa could be prevented in half of patients. The overall findings of this survey support the need for studies on routes of transmission and risk assessment approach to better define how to control exogenous acquisition in ICUs.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.subject.enPulsed-field gel electrophoresis
dc.subject.enWater taps
dc.subject.enPseudomonas aeruginosa
dc.subject.enIntensive care unit
dc.title.enExogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multi-centre study (DYNAPYO study)
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jhin.2019.08.008en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
bordeaux.journalJournal of Hospital Infectionen_US
bordeaux.page40-45en_US
bordeaux.volume104en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03161089
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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