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Physical and mental health status of former smokers and non-smokers patients with bipolar disorder

dc.rights.licenseopenen_US
dc.contributor.authorNOBILE, Benedicte
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorGARD, Sebastien
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorBROUSSE, Georges
dc.contributor.authorLOFTUS, Josephine
dc.contributor.authorAUBIN, Valerie
dc.contributor.authorBELZEAUX, Raoul
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorLE STRAT, Yann
dc.contributor.authorMAZER, Nicolas
dc.contributor.authorDE PREMOREL, Alix
dc.contributor.authorROUX, Paul
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorSCHWINTZER, Thomas
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorCOLLABORATORS, FondaMental Advanced Center Of Expertise For Bipolar Disorders (FACE-BD)
dc.contributor.authorBISEUL, Isabelle
dc.contributor.authorETAIN, Bruno
dc.contributor.authorMOIRAND, Remi
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorLEBOYER, Marion
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorGUILLAUME, Sebastien
dc.contributor.authorICICK, Romain
dc.date.accessioned2023-05-30T08:16:25Z
dc.date.available2023-05-30T08:16:25Z
dc.date.issued2023-02-07
dc.identifier.issn1600-0447en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182355
dc.description.abstractEnObjectives Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and nonpsychiatric correlates of tobacco smoking status (never- vs. current vs. former smokers) in individuals with BD. Methods 3860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g., BD type, current symptoms load, and non-psychiatric morbidity—including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied. Results Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers—suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics. Conclusions Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enaddiction
dc.subject.enbipolar disorder
dc.subject.enformer smokers
dc.subject.enmetabolic syndrome
dc.subject.entobacco
dc.title.enPhysical and mental health status of former smokers and non-smokers patients with bipolar disorder
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/acps.13535en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36751870en_US
bordeaux.journalActa Psychiatrica Scandinavicaen_US
bordeaux.page373-388en_US
bordeaux.volume147en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Psychiatrica%20Scandinavica&rft.date=2023-02-07&rft.volume=147&rft.issue=4&rft.spage=373-388&rft.epage=373-388&rft.eissn=1600-0447&rft.issn=1600-0447&rft.au=NOBILE,%20Benedicte&GODIN,%20Ophelia&GARD,%20Sebastien&SAMALIN,%20Ludovic&BROUSSE,%20Georges&rft.genre=article


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