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Acute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid in rats

dc.rights.licenseopenen_US
dc.contributor.authorBATANDIER, C.
dc.contributor.authorPOYOT, T.
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMARISSAL-ARVY, Nathalie
dc.contributor.authorCOUTURIER, K.
dc.contributor.authorCANINI, F.
dc.contributor.authorROUSSEL, A.M.
dc.contributor.authorHININGER-FAVIER, I.
dc.date.accessioned2023-05-24T10:57:02Z
dc.date.available2023-05-24T10:57:02Z
dc.date.issued2020-07
dc.identifier.issn0271-5317en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182300
dc.description.abstractEnStudies focusing on the interaction of dietary and acute emotional stress on oxidative stress in cortex frontal and in brain mitochondria are scarce. Dietary-induced insulin resistance, as observed in Western diets, has been associated with increased oxidative stress causing mitochondrial dysfunction. We hypothesized that acute emotional stress could be an aggravating factor by impacting redox status in cortex and brain mitochondria. Thus, the aim of the present study was to evaluate the combination of an insulin resistance inducing high-fat/high-fructose (HF/HFr) diet and acute emotional stress on brain oxidative stress in rats. We measured several oxidative stress parameters (carbonyls, FRAP, TBARS assays, GSH, GSSG, oxidized DNA, mRNA expression of redox proteins (Nrf2), and uric acid). The HF/HFr diet resulted in increased oxidative stress both in the brain mitochondria and in the frontal cortex and decreased expression of the Nrf2 gene. The emotional stress induced an oxidative response in plasma and in brain mitochondria of the control group. In the HF/HFr group it triggered an increase expression of the redox transcription factor Nrf2 and its downstream antioxidant genes. This suggests an improvement of the redox stress tolerance in response to an enhanced production of reactive oxygen species. Accordingly, a blunted oxidative effect on several markers was observed in plasma and brain of HF/HFr-stressed group. This was confirmed in a parallel study using lipopolysaccharide as a stress model. Beside the Nrf2 increase, the stress induced a stronger UA release in HF/HFr which could take a part in the redox stress.
dc.description.sponsorshipCerveau, résistance à l'insuline et mitochondrie :Rôle neuroprotecteur des polyphénols de la cannelle dans un modèle animal de syndrome métabolique - ANR-07-PNRA-0003en_US
dc.language.isoENen_US
dc.subject.enAcute stress
dc.subject.enBrain
dc.subject.enHigh-fat/high-fructose diet
dc.subject.enOxidative stress
dc.subject.enRedox signaling
dc.subject.meshAnimals
dc.subject.meshAntioxidants
dc.subject.meshNF-E2-Related Factor 2
dc.subject.meshOxidation-Reduction
dc.subject.meshOxidative Stress
dc.subject.meshPsychological Distress
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshReactive Oxygen Species
dc.subject.meshUric Acid
dc.subject.meshBrain
dc.subject.meshDiet, High-Fat
dc.subject.meshDiet, Western
dc.subject.meshDietary Sugars
dc.subject.meshFructose
dc.subject.meshGene Expression Regulation
dc.subject.meshMale
dc.subject.meshMitochondria
dc.title.enAcute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid in rats
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.nutres.2020.05.009en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed32610255en_US
bordeaux.journalNutrition Researchen_US
bordeaux.page23-34en_US
bordeaux.volume79en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03349602
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrition%20Research&rft.date=2020-07&rft.volume=79&rft.spage=23-34&rft.epage=23-34&rft.eissn=0271-5317&rft.issn=0271-5317&rft.au=BATANDIER,%20C.&POYOT,%20T.&MARISSAL-ARVY,%20Nathalie&COUTURIER,%20K.&CANINI,%20F.&rft.genre=article


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