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dc.rights.licenseopenen_US
dc.contributor.authorGAROFALO, Stefano
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorPICARD, Katherine
dc.contributor.authorLIMATOLA, Cristina
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorNADJAR, Agnes
dc.contributor.authorPASCUAL, Olivier
dc.contributor.authorTREMBLAY, Marie-Eve
dc.date.accessioned2023-05-24T09:34:07Z
dc.date.available2023-05-24T09:34:07Z
dc.date.issued2020-04
dc.identifier.issn2040-4603en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182292
dc.description.abstractEnSleep is a naturally occurring physiological state that is required to sustain physical and mental health. Traditionally viewed as strictly regulated by top-down control mechanisms, sleep is now known to also originate locally. Glial cells are emerging as important contributors to the regulation of sleep-wake cycles, locally and among dedicated neural circuits. A few pioneering studies revealed that astrocytes and microglia may influence sleep pressure, duration as well as intensity, but the precise involvement of these two glial cells in the regulation of sleep remains to be fully addressed, across contexts of health and disease. In this overview article, we will first summarize the literature pertaining to the role of astrocytes and microglia in the regulation of sleep under normal physiological conditions. Afterward, we will discuss the beneficial and deleterious consequences of glia-mediated neuroinflammation, whether it is acute, or chronic and associated with brain diseases, on the regulation of sleep. Sleep disturbances are a main comorbidity in neurodegenerative diseases, and in several brain diseases that include pain, epilepsy, and cancer. Identifying the relationships between glia-mediated neuroinflammation, sleep-wake rhythm disruption and brain diseases may have important implications for the treatment of several disorders.
dc.language.isoENen_US
dc.subjectmicroglie
dc.subjectsante humaine
dc.subjectsommeil
dc.subjectneuroinflammation
dc.subjectmaladie cérébrale
dc.title.enRole of glia in the regulation of sleep in health and disease
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/cphy.c190022en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.subject.halSciences cognitives/Neurosciencesen_US
dc.identifier.pubmed32163207en_US
bordeaux.journalComprehensive Physiologyen_US
bordeaux.page687-712en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02528992
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Comprehensive%20Physiology&rft.date=2020-04&rft.volume=10&rft.issue=2&rft.spage=687-712&rft.epage=687-712&rft.eissn=2040-4603&rft.issn=2040-4603&rft.au=GAROFALO,%20Stefano&PICARD,%20Katherine&LIMATOLA,%20Cristina&NADJAR,%20Agnes&PASCUAL,%20Olivier&rft.genre=article


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