| dc.rights.license | open | en_US |
| dc.contributor.author | BLAZQUEZ, Cristina | |
| dc.contributor.author | RUIZ-CALVO, Andrea | |
| dc.contributor.author | BAJO-GRANERAS, Raquel | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BAUFRETON, Jerome M. | |
| dc.contributor.author | RESEL, Eva | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | VARILH, Marjorie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PAGANO ZOTTOLA, Antonio C. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARIANI, Yamuna | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CANNICH, Astrid | |
| dc.contributor.author | RODRIGUEZ-NAVARRO, Jose A. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.contributor.author | GALVE-ROPERH, Ismael | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BELLOCCHIO, Luigi | |
| dc.contributor.author | GUZMAN, Manuel | |
| dc.date.accessioned | 2023-05-24T09:04:03Z | |
| dc.date.available | 2023-05-24T09:04:03Z | |
| dc.date.issued | 2020-08-10 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182286 | |
| dc.description.abstractEn | The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that ∆9-tetrahydrocannabinol, the psychoactive ingredient of cannabis, disrupts autophagy selectively in the striatum, a brain area that controls motor behavior, both in vitro and in vivo. Boosting autophagy, either pharmacologically (with temsirolimus) or by dietary intervention (with trehalose), rescued the ∆9-tetrahydrocannabinol-induced impairment of motor coordination in mice. The combination of conditional knockout mouse models and viral vector-mediated autophagy-modulating strategies in vivo showed that cannabinoid CB1 receptors located on neurons belonging to the direct (striatonigral) pathway are required for the motor-impairing activity of ∆9-tetrahydrocannabinol by inhibiting local autophagy. Taken together, these findings identify inhibition of autophagy as an unprecedented mechanistic link between cannabinoids and motor performance, and suggest that activators of autophagy might be considered as potential therapeutic tools to treat specific cannabinoid-evoked behavioral alterations. © Blázquez et al. | |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Représentation sensorielle lors d'états psychotiques | en_US |
| dc.description.sponsorship | Recepteurs aux cannabinoides dans le codage visuel cortical - ANR-18-CE16-0001 | en_US |
| dc.description.sponsorship | Role du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetique | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Autophagy | |
| dc.subject.en | Cannabinoid | |
| dc.subject.en | Drug abuse | |
| dc.subject.en | mTOR | |
| dc.subject.en | Motor behaviour | |
| dc.subject.en | Mouse | |
| dc.subject.en | Neuroscience | |
| dc.subject.en | Striatum | |
| dc.title.en | Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination | |
| dc.title.alternative | Elife | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.7554/ELIFE.56811 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32773031 | en_US |
| dc.description.sponsorshipEurope | Neurocircuitry of endocannabinoid regulation of food intake | en_US |
| dc.description.sponsorshipEurope | Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes | en_US |
| bordeaux.journal | Elife | en_US |
| bordeaux.page | 1-24 | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Ministerio de Ciencia, Innovación y Universidades | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Human Frontier Science Program | en_US |
| bordeaux.identifier.funderID | H2020 European Research Council | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Elife&rft.date=2020-08-10&rft.volume=9&rft.spage=1-24&rft.epage=1-24&rft.au=BLAZQUEZ,%20Cristina&RUIZ-CALVO,%20Andrea&BAJO-GRANERAS,%20Raquel&BAUFRETON,%20Jerome%20M.&RESEL,%20Eva&rft.genre=article | |
