| dc.rights.license | open | en_US |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | SALA, Margaux | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GONZALES, Delphine | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LESTE-LASSERRE, Thierry | |
| hal.structure.identifier | TBM-Core [Bordeaux] [UMS3427 - INSERM US005] | |
| dc.contributor.author | DUGOT-SENANT, Nathalie | |
| dc.contributor.author | PARADIS, Valerie | |
| hal.structure.identifier | TBM-Core [Bordeaux] [UMS3427 - INSERM US005] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | DI TOMMASO, Sylvaine | |
| hal.structure.identifier | Centre Génomique Fonctionnelle Bordeaux [Bordeaux] [CGFB] | |
| hal.structure.identifier | Plateforme Protéome [Bordeaux] | |
| dc.contributor.author | DUPUY, Jean-William | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | PITARD, Vincent | |
| hal.structure.identifier | TBM-Core [Bordeaux] [UMS3427 - INSERM US005] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | DOURTHE, Cyril | |
| dc.contributor.author | SCIARRA, Amadeo | |
| dc.contributor.author | SEMPOUX, Christine | |
| dc.contributor.author | FERRELL, Linda D. | |
| dc.contributor.author | CLOUSTON, Andrew D. | |
| dc.contributor.author | MILLER, Gregory | |
| dc.contributor.author | YEH, Mathew M. | |
| dc.contributor.author | THUNG, Swan | |
| dc.contributor.author | GOUW, Annette S.H. | |
| dc.contributor.author | QUAGLIA, Alberto | |
| dc.contributor.author | HAN, Jing | |
| dc.contributor.author | HUAN, Ji | |
| dc.contributor.author | FAN, Cathy | |
| dc.contributor.author | CRAWFORD, James | |
| dc.contributor.author | NAKANUMA, Yasuni | |
| dc.contributor.author | HARADA, Kenichi | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | LE BAIL, Brigitte | |
| dc.contributor.author | CASTAIN, Claire | |
| dc.contributor.author | FRULIO, Nora | |
| hal.structure.identifier | Imagerie moléculaire et thérapies innovantes en oncologie [IMOTION] | |
| dc.contributor.author | TRILLAUD, Herve | |
| dc.contributor.author | POSSENTI, Laurent | |
| dc.contributor.author | CHICHE, Laurence | |
| dc.contributor.author | LAURENT, Christophe | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | BIOULAC-SAGE, Paulette | |
| hal.structure.identifier | TBM-Core [Bordeaux] [UMS3427 - INSERM US005] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | RAYMOND, Anne-Aurelie | |
| hal.structure.identifier | TBM-Core [Bordeaux] [UMS3427 - INSERM US005] | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | SALTEL, Frederic | |
| dc.date.accessioned | 2023-05-23T14:56:02Z | |
| dc.date.available | 2023-05-23T14:56:02Z | |
| dc.date.issued | 2020-04-11 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182279 | |
| dc.description.abstractEn | Until recently, 10% of hepatocellular adenomas (HCAs) remained unclassified (UHCA). Among the UHCAs, the sonic hedgehog HCA (shHCA) was defined by focal deletions that fuse the promoter of Inhibin beta E chain with GLI1. Prostaglandin D2 synthase was proposed as immunomarker. In parallel, our previous work using proteomic analysis showed that most UHCAs constitute a homogeneous subtype associated with overexpression of argininosuccinate synthase (ASS1). To clarify the use of ASS1 in the HCA classification and avoid misinterpretations of the immunohistochemical staining, the aims of this work were to study (1) the link between shHCA and ASS1 overexpression and (2) the clinical relevance of ASS1 overexpression for diagnosis. Molecular, proteomic, and immunohistochemical analyses were performed in UHCA cases of the Bordeaux series. The clinico-pathological features, including ASS1 immunohistochemical labeling, were analyzed on a large international series of 67 cases. ASS1 overexpression and the shHCA subgroup were superimposed in 15 cases studied by molecular analysis, establishing ASS1 overexpression as a hallmark of shHCA. Moreover, the ASS1 immunomarker was better than prostaglandin D2 synthase and only found positive in 7 of 22 shHCAs. Of the 67 UHCA cases, 58 (85.3%) overexpressed ASS1, four cases were ASS1 negative, and in five cases ASS1 was noncontributory. Proteomic analysis performed in the case of doubtful interpretation of ASS1 overexpression, especially on biopsies, can be a support to interpret such cases. ASS1 overexpression is a specific hallmark of shHCA known to be at high risk of bleeding. Therefore, ASS1 is an additional tool for HCA classification and clinical diagnosis. © 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Argininosuccinate Synthase | |
| dc.subject.en | Glutamate Ammonia Ligase | |
| dc.subject.en | Hemagglutinin | |
| dc.subject.en | Prostaglandin D2 | |
| dc.subject.en | Serum Amyloid A | |
| dc.subject.en | Small Interfering Rna | |
| dc.subject.en | Sonic Hedgehog Protein | |
| dc.subject.en | Vimentin | |
| dc.subject.en | Article | |
| dc.subject.en | Ass1 Gene | |
| dc.subject.en | Body Mass | |
| dc.subject.en | Clinical Practice | |
| dc.subject.en | Disease Association | |
| dc.subject.en | Gene | |
| dc.subject.en | Gene Overexpression | |
| dc.subject.en | Genetic Transfection | |
| dc.subject.en | Genotyping Technique | |
| dc.subject.en | Hedgehog Signaling | |
| dc.subject.en | Human | |
| dc.subject.en | Human Tissue | |
| dc.subject.en | Immunohistochemistry | |
| dc.subject.en | Liquid Chromatography-Mass Spectrometry | |
| dc.subject.en | Liver Adenoma | |
| dc.subject.en | Liver Fibrosis | |
| dc.subject.en | Liver Injury | |
| dc.subject.en | Metabolic Syndrome X | |
| dc.subject.en | Microarray Analysis | |
| dc.subject.en | Obesity | |
| dc.subject.en | Phenotype | |
| dc.subject.en | Priority Journal | |
| dc.subject.en | Promoter Region | |
| dc.subject.en | Protein Expression | |
| dc.subject.en | Proteomics | |
| dc.subject.en | Real Time Reverse Transcription Polymerase Chain Reaction | |
| dc.subject.en | Risk Factor | |
| dc.subject.en | Rna Extraction | |
| dc.subject.en | Rna Isolation | |
| dc.subject.en | Tumor Recurrence | |
| dc.subject.en | Upregulation | |
| dc.subject.en | Western Blotting | |
| dc.title.en | ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice | |
| dc.title.alternative | Hepatol Commun | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/hep4.1514 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 32490318 | en_US |
| bordeaux.journal | Hepatology Communications | en_US |
| bordeaux.page | 809-824 | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Plateforme Transcriptome | en_US |
| bordeaux.team | Génotypage | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04104081 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-05-23T14:56:19Z | |
| hal.export | true | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Hepatology%20Communications&rft.date=2020-04-11&rft.volume=4&rft.issue=6&rft.spage=809-824&rft.epage=809-824&rft.au=SALA,%20Margaux&GONZALES,%20Delphine&LESTE-LASSERRE,%20Thierry&DUGOT-SENANT,%20Nathalie&PARADIS,%20Valerie&rft.genre=article | |
