Accuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FERTE, Thomas | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RAMEL, Viviane | |
| dc.contributor.author | CAZANAVE, Charles | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LAFON, Marie-Edith | |
| dc.contributor.author | BEBEAR, Cecile | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MALVY, Denis
ORCID: 0000-0003-1948-9355 IDREF: 148480993 | |
| dc.contributor.author | GEORGES-WALRYCK, Agnes | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DEHAIL, Patrick | |
| dc.date.accessioned | 2023-05-22T14:08:51Z | |
| dc.date.available | 2023-05-22T14:08:51Z | |
| dc.date.issued | 2021-06-05 | |
| dc.identifier.issn | 1386-6532 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182237 | |
| dc.description.abstractEn | OBJECTIVE: There is a lack of data evaluating performance of antigenic test (AT) for SARS-CoV-2 diagnosis (Ag-RDT) in clinical practice, especially in asymptomatic subjects. The main objective of this study was to evaluate the diagnostic performance of AT compared to Reverse Transcription Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 diagnosis. METHODS: StudyCov is a monocentric cross-sectional study. A SARS-CoV-2 screening facility was set up in the Bordeaux University health campus from October 28th to November 20th 2020. Students willing to have a RT-PCR test (ARGENE SARS-CoV-2 R-GENE, BioMerieux, France) for SARS-CoV-2 diagnosis were also offered the Abbott Panbio SARS-CoV-2 antigenic rapid test. All participants attending the screening facility with an AT in addition to RT-PCR and having signed an informed consent were included in the study. The main objective was to assess performance of AT as compared with RT-PCR in the recruited population. Secondary objectives dealt with the analysis of the main objective stratified by current symptoms and risk exposure. A sensitivity analysis with different RT-PCR cycle thresholds was included. RESULTS: RT-PCR and AT results were available for 692 subjects. Overall sensitivity and specificity of AT tests were respectively 63.5% (95% confidence interval (CI): 49.0 - 76.4) and 100% (95% CI: 99.4 - 100). In the asymptomatic sub-group, they were respectively 35.0% (95% CI: 15.4% - 59.2%) and 100% (95% CI: 99.3 - 100). CONCLUSIONS: This study shows the poor sensitivity of AT in asymptomatic subjects, specificity being however excellent. The performance results fall below the World Health Organization recommendation of 80% sensitivity and question using AT in general population, especially when asymptomatic. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Rapid antigen detection test | |
| dc.subject.en | Sars-cov-2 | |
| dc.subject.en | Rt-pcr | |
| dc.subject.en | Point-of-care testing | |
| dc.subject.en | COVID19 | |
| dc.title.en | Accuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jcv.2021.104878 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | Journal of Clinical Virology | en_US |
| bordeaux.page | 104878 | en_US |
| bordeaux.volume | 141 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03287513 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
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