Afficher la notice abrégée

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFERTE, Thomas
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAMEL, Viviane
dc.contributor.authorCAZANAVE, Charles
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAFON, Marie-Edith
dc.contributor.authorBEBEAR, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALVY, Denis
ORCID: 0000-0003-1948-9355
IDREF: 148480993
dc.contributor.authorGEORGES-WALRYCK, Agnes
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEHAIL, Patrick
dc.date.accessioned2023-05-22T14:08:51Z
dc.date.available2023-05-22T14:08:51Z
dc.date.issued2021-06-05
dc.identifier.issn1386-6532en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182237
dc.description.abstractEnOBJECTIVE: There is a lack of data evaluating performance of antigenic test (AT) for SARS-CoV-2 diagnosis (Ag-RDT) in clinical practice, especially in asymptomatic subjects. The main objective of this study was to evaluate the diagnostic performance of AT compared to Reverse Transcription Polymerase Chain Reaction (RT-PCR) for SARS-CoV-2 diagnosis. METHODS: StudyCov is a monocentric cross-sectional study. A SARS-CoV-2 screening facility was set up in the Bordeaux University health campus from October 28th to November 20th 2020. Students willing to have a RT-PCR test (ARGENE SARS-CoV-2 R-GENE, BioMerieux, France) for SARS-CoV-2 diagnosis were also offered the Abbott Panbio SARS-CoV-2 antigenic rapid test. All participants attending the screening facility with an AT in addition to RT-PCR and having signed an informed consent were included in the study. The main objective was to assess performance of AT as compared with RT-PCR in the recruited population. Secondary objectives dealt with the analysis of the main objective stratified by current symptoms and risk exposure. A sensitivity analysis with different RT-PCR cycle thresholds was included. RESULTS: RT-PCR and AT results were available for 692 subjects. Overall sensitivity and specificity of AT tests were respectively 63.5% (95% confidence interval (CI): 49.0 - 76.4) and 100% (95% CI: 99.4 - 100). In the asymptomatic sub-group, they were respectively 35.0% (95% CI: 15.4% - 59.2%) and 100% (95% CI: 99.3 - 100). CONCLUSIONS: This study shows the poor sensitivity of AT in asymptomatic subjects, specificity being however excellent. The performance results fall below the World Health Organization recommendation of 80% sensitivity and question using AT in general population, especially when asymptomatic.
dc.language.isoENen_US
dc.subject.enRapid antigen detection test
dc.subject.enSars-cov-2
dc.subject.enRt-pcr
dc.subject.enPoint-of-care testing
dc.subject.enCOVID19
dc.title.enAccuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jcv.2021.104878en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalJournal of Clinical Virologyen_US
bordeaux.page104878en_US
bordeaux.volume141en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03287513
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Virology&rft.date=2021-06-05&rft.volume=141&rft.spage=104878&rft.epage=104878&rft.eissn=1386-6532&rft.issn=1386-6532&rft.au=FERTE,%20Thomas&RAMEL,%20Viviane&CAZANAVE,%20Charles&LAFON,%20Marie-Edith&BEBEAR,%20Cecile&rft.genre=article


Fichier(s) constituant ce document

Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée