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Handedness as a neurodevelopmental marker in schizophrenia: Results from the FACE-SZ cohort
dc.rights.license | open | en_US |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm] | |
dc.contributor.author | MALLET, Jasmina | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | GODIN, Ophelia | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | LE STRAT, Yann | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Hôpital Louis Mourier - AP-HP [Colombes] | |
hal.structure.identifier | Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm] | |
dc.contributor.author | MAZER, Nicolas | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Fédération de Médecine Translationnelle de Strasbourg [FMTS] | |
dc.contributor.author | BERNA, Fabrice | |
dc.contributor.author | BOYER, L. | |
dc.contributor.author | CAPDEVIELLE, D. | |
dc.contributor.author | CLAUSS, J. | |
hal.structure.identifier | CHU Clermont-Ferrand | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | CHEREAU, Isabelle | |
hal.structure.identifier | Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL] | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | D'AMATO, Thierry | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | DUBREUCQ, Julien | |
dc.contributor.author | LEIGNER, S. | |
dc.contributor.author | LLORCA, P.-M. | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
dc.contributor.author | MISDRAHI, David | |
dc.contributor.author | PASSERIEUX, C. | |
dc.contributor.author | REY, R. | |
dc.contributor.author | PIGNON, B. | |
dc.contributor.author | URBACH, M. | |
hal.structure.identifier | Fondation FondaMental [Créteil] | |
dc.contributor.author | SCHURHOFF, Franck | |
dc.contributor.author | FOND, G. | |
dc.contributor.author | DUBERTRET, C. | |
dc.contributor.author | THE, FACE-SZ, (FondaMental, Academic, Center, Of, Expertise, For, Schizophrenia, Group) | |
dc.date.accessioned | 2023-05-22T13:32:17Z | |
dc.date.available | 2023-05-22T13:32:17Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1562-2975 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182228 | |
dc.description.abstractEn | Objectives: High rates of non-right-handedness (NRH) including mixed-handedness have been reported in neurodevelopmental disorders. In schizophrenia (SZ), atypical handedness has been inconsistently related to impaired features. We aimed to determine whether SZ subjects with NRH and mixed-handedness had poorer clinical and cognitive outcomes compared to their counterparts. Methods: 667 participants were tested with a battery of neuropsychological tests, and assessed for laterality using the Edinburg Handedness Inventory. Clinical symptomatology was assessed. Learning disorders and obstetrical complications were recorded. Biological parameters were explored. Results: The prevalence of NRH and mixed-handedness was high (respectively, 42.4% and 34.1%). In the multivariable analyses, NRH was associated with cannabis use disorder (p = 0.045). Mixed-handedness was associated with positive symptoms (p = 0.041), current depressive disorder (p = 0.005)), current cannabis use (p = 0.024) and less akathisia (p = 0.019). A history of learning disorder was associated with NRH. No association was found with cognition, trauma history, obstetrical complications, psychotic symptoms, peripheral inflammation. Conclusions: Non-right and mixed-handedness are very high in patients with SZ, possibly reflecting a neurodevelopmental origin. NRH is associated with learning disorders and cannabis use. Mixed-handedness is associated with positive symptoms, current depressive disorder, cannabis use and less akathisia. However, this study did not confirm greater cognitive impairment in these patients. © 2021 Informa UK Limited, trading as Taylor & Francis Group. | |
dc.description.sponsorship | Sorbonne Universités à Paris pour l'Enseignement et la Recherche | en_US |
dc.description.sponsorship | FondaMental-Cohortes - ANR-10-COHO-0010 | en_US |
dc.language.iso | EN | en_US |
dc.subject.en | Schizophrenia | |
dc.subject.en | Psychosis | |
dc.subject.en | Cognition | |
dc.subject.en | Neurodevelopment | |
dc.subject.en | Handedness | |
dc.title.en | Handedness as a neurodevelopmental marker in schizophrenia: Results from the FACE-SZ cohort | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1080/15622975.2021.2013094 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 34918618 | en_US |
bordeaux.journal | World Journal of Biological Psychiatry | en_US |
bordeaux.page | 525-536 | en_US |
bordeaux.volume | 23 | en_US |
bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
bordeaux.issue | 7 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INRAE | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
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hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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