Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders
| dc.rights.license | open | en_US |
| hal.structure.identifier | Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)] | |
| dc.contributor.author | GRILLAULT LAROCHE, Diane | |
| dc.contributor.author | GODIN, O. | |
| dc.contributor.author | DANSOU, Y. | |
| hal.structure.identifier | Assistance Publique - Hôpitaux de Marseille [APHM] | |
| hal.structure.identifier | Fondation FondaMental [Créteil] | |
| dc.contributor.author | BELZEAUX, Raoul | |
| hal.structure.identifier | Centre hospitalier Charles Perrens [Bordeaux] | |
| hal.structure.identifier | Fondation FondaMental [Créteil] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | AOUIZERATE, Bruno
IDREF: 069471851 | |
| dc.contributor.author | BURTÉ, T. | |
| hal.structure.identifier | Fondation FondaMental [Créteil] | |
| dc.contributor.author | COURTET, Philippe | |
| hal.structure.identifier | Hôpital Louis Mourier - AP-HP [Colombes] | |
| dc.contributor.author | DUBERTRET, Caroline | |
| dc.contributor.author | HAFFEN, E. | |
| dc.contributor.author | LLORCA, P.M. | |
| dc.contributor.author | OLIE, E. | |
| dc.contributor.author | ROUX, P. | |
| dc.contributor.author | POLOSAN, M. | |
| dc.contributor.author | SCHWAN, R. | |
| dc.contributor.author | LEBOYER, M. | |
| dc.contributor.author | BELLIVIER, F. | |
| dc.contributor.author | MARIE-CLAIRE, C. | |
| dc.contributor.author | ETAIN, B. | |
| dc.date.accessioned | 2023-05-17T14:12:19Z | |
| dc.date.available | 2023-05-17T14:12:19Z | |
| dc.date.issued | 2022-01 | |
| dc.identifier.issn | 0924-9338 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182202 | |
| dc.description.abstractEn | Background Psychiatric comorbidities and suicide attempts are highly prevalent in Bipolar Disorders (BD). We examined the associations between childhood maltreatment, psychiatric comorbidities, and suicide attempts, in terms of lifetime prevalence, sequence of onset, and current symptoms.Methods We assessed 3,047 individuals with BD for suicide attempts, anxiety disorders, substance use disorders, and eating disorders. Participants completed a self-report for the assessment of childhood maltreatment. Associations between childhood maltreatment and characteristics of comorbidities (lifetime prevalence, current symptoms, and age at onset) were examined using logistic regressions and network analyses.Results Psychiatric comorbidities were frequent with a mean number per individual of 1.23 (SDÂ =Â 1.4). Most comorbidities occurred prior to the onset of BD. Participants who reported higher levels of childhood maltreatment had more frequent and multiple comorbidities, which were also more currently active at inclusion. Childhood maltreatment did not decrease the age of onset of comorbidities, but was associated with a faster accumulation of comorbidities prior to the onset of BD. Logistic regression and network analyses showed that emotional abuse and sexual abuse might play a prominent role in the lifetime prevalence of psychiatric comorbidities and suicide attempts.Conclusions Childhood maltreatment was associated with suicide attempts, and with frequent, multiple, and persistent psychiatric comorbidities that accumulated more rapidly prior to the onset of BD. Hence, childhood maltreatment should be systematically assessed in individuals with BD, in particular when the course of the disorder is characterized by a high comorbid profile or by a high suicidality. © 2022 Elsevier Masson SAS. All rights reserved. | |
| dc.description.sponsorship | Sorbonne Universités à Paris pour l'Enseignement et la Recherche | en_US |
| dc.description.sponsorship | FondaMental-Cohortes - ANR-10-COHO-0010 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Bipolar disorder | |
| dc.subject.en | Childhood maltreatment | |
| dc.subject.en | Comorbidities | |
| dc.subject.en | Prevalence | |
| dc.subject.en | Suicide | |
| dc.title.en | Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1192/j.eurpsy.2022.7 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| bordeaux.journal | European Psychiatry | en_US |
| bordeaux.volume | 65 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation FondaMental | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Psychiatry&rft.date=2022-01&rft.volume=65&rft.issue=1&rft.eissn=0924-9338&rft.issn=0924-9338&rft.au=GRILLAULT%20LAROCHE,%20Diane&GODIN,%20O.&DANSOU,%20Y.&BELZEAUX,%20Raoul&AOUIZERATE,%20Bruno&rft.genre=article |
