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Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders

dc.rights.licenseopenen_US
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorGRILLAULT LAROCHE, Diane
dc.contributor.authorGODIN, O.
dc.contributor.authorDANSOU, Y.
hal.structure.identifierAssistance Publique - Hôpitaux de Marseille [APHM]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorBURTÉ, T.
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorHAFFEN, E.
dc.contributor.authorLLORCA, P.M.
dc.contributor.authorOLIE, E.
dc.contributor.authorROUX, P.
dc.contributor.authorPOLOSAN, M.
dc.contributor.authorSCHWAN, R.
dc.contributor.authorLEBOYER, M.
dc.contributor.authorBELLIVIER, F.
dc.contributor.authorMARIE-CLAIRE, C.
dc.contributor.authorETAIN, B.
dc.date.accessioned2023-05-17T14:12:19Z
dc.date.available2023-05-17T14:12:19Z
dc.date.issued2022-01
dc.identifier.issn0924-9338en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182202
dc.description.abstractEnBackground Psychiatric comorbidities and suicide attempts are highly prevalent in Bipolar Disorders (BD). We examined the associations between childhood maltreatment, psychiatric comorbidities, and suicide attempts, in terms of lifetime prevalence, sequence of onset, and current symptoms.Methods We assessed 3,047 individuals with BD for suicide attempts, anxiety disorders, substance use disorders, and eating disorders. Participants completed a self-report for the assessment of childhood maltreatment. Associations between childhood maltreatment and characteristics of comorbidities (lifetime prevalence, current symptoms, and age at onset) were examined using logistic regressions and network analyses.Results Psychiatric comorbidities were frequent with a mean number per individual of 1.23 (SDÂ =Â 1.4). Most comorbidities occurred prior to the onset of BD. Participants who reported higher levels of childhood maltreatment had more frequent and multiple comorbidities, which were also more currently active at inclusion. Childhood maltreatment did not decrease the age of onset of comorbidities, but was associated with a faster accumulation of comorbidities prior to the onset of BD. Logistic regression and network analyses showed that emotional abuse and sexual abuse might play a prominent role in the lifetime prevalence of psychiatric comorbidities and suicide attempts.Conclusions Childhood maltreatment was associated with suicide attempts, and with frequent, multiple, and persistent psychiatric comorbidities that accumulated more rapidly prior to the onset of BD. Hence, childhood maltreatment should be systematically assessed in individuals with BD, in particular when the course of the disorder is characterized by a high comorbid profile or by a high suicidality. © 2022 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Recherche - ANR-11-IDEX-0004en_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBipolar disorder
dc.subject.enChildhood maltreatment
dc.subject.enComorbidities
dc.subject.enPrevalence
dc.subject.enSuicide
dc.title.enInfluence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders
dc.typeArticle de revueen_US
dc.identifier.doi10.1192/j.eurpsy.2022.7en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalEuropean Psychiatryen_US
bordeaux.volume65en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Psychiatry&rft.date=2022-01&rft.volume=65&rft.issue=1&rft.eissn=0924-9338&rft.issn=0924-9338&rft.au=GRILLAULT%20LAROCHE,%20Diane&GODIN,%20O.&DANSOU,%20Y.&BELZEAUX,%20Raoul&AOUIZERATE,%20Bruno&rft.genre=article


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