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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorSOUBEYRE, Vanessa
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorMERLE, Laetitia
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorJARRIAULT, David
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorGREGOIRE, Stephane
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorBRETILLON, Lionel
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorACAR, Niyazi
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorGROSMAITRE, Xavier
hal.structure.identifierCentre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
dc.contributor.authorLE BON, Anne-Marie
dc.date.accessioned2023-05-17T08:35:21Z
dc.date.available2023-05-17T08:35:21Z
dc.date.issued2022-06
dc.identifier.issn1028-415Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182189
dc.description.abstractEnBackground and objective: We recently showed that perinatal exposure to diets with unbalanced n-6:n-3 polyunsaturated fatty acid (PUFA) ratios affects the olfactory mucosa (OM) fatty acid composition. To assess the repercussions of these modifications, we investigated the impact of diets unbalanced in n-3 PUFAs on the molecular composition and functionality of the OM in young mice. Methods: After mating, female mice were fed diets either deficient in α-linolenic acid (LOW diet) or supplemented with n-3 long-chain PUFAs (HIGH diet) during the perinatal period. Weaned male offspring were then fed ad libitum with the same experimental diets for 5 weeks. At 8 weeks of age, olfactory behavior tests were performed in young mice. The fatty acid composition of OM and olfactory cilia, as well as the expression of genes involved in different cellular pathways, were analyzed. The electroolfactograms induced by odorant stimuli were recorded to assess the impact of diets on OM functionality. Results and conclusion: Both diets significantly modified the fatty acid profiles of OM and olfactory cilia in young mice. They also induced changes in the expression of genes involved in olfactory signaling and in olfactory neuron maturation. The electroolfactogram amplitudes were reduced in mice fed the LOW diet. Nevertheless, the LOW diet and the HIGH diet did not affect mouse olfactory behavior. Our study demonstrated that consumption of diets deficient in or supplemented with n-3 PUFAs during the perinatal and postweaning periods caused significant changes in young mouse OM. However, these modifications did not impair their olfactory capacities. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enOlfaction
dc.subject.enOlfactory mucosa
dc.subject.enElectroolfactogram
dc.subject.enOlfactorybehavior
dc.subject.enOfactory cilia
dc.subject.enFattyacid
dc.subject.enMaternal diet
dc.subject.enMouse
dc.title.enDietary n-3 polyunsaturated fatty acid deficiency alters olfactory mucosa sensitivity in young mice but has no impact on olfactory behavior
dc.typeArticle de revueen_US
dc.identifier.doi10.1080/1028415X.2022.2082642en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35694841en_US
bordeaux.journalNutritional Neuroscienceen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutritional%20Neuroscience&rft.date=2022-06&rft.eissn=1028-415X&rft.issn=1028-415X&rft.au=SOUBEYRE,%20Vanessa&MERLE,%20Laetitia&JARRIAULT,%20David&GREGOIRE,%20Stephane&BRETILLON,%20Lionel&rft.genre=article


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