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The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort

dc.rights.licenseopenen_US
dc.contributor.authorGAROSI, Alexandra
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorSUBHARY DE VERVILLE, Pierre-Louis
dc.contributor.authorETCHECOPAR-ETCHART, D.
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorRICHIERI, Raphaelle
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorSCHURHOFF, Franck
dc.contributor.authorBERNA, F.
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCAPDEVIELLE, Delphine
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCHEREAU, Isabelle
dc.contributor.authorCLAUSS-KOBAYASHI, J.
dc.contributor.authorDOREY, J.M.
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorCOULON, N.
dc.contributor.authorLEIGNIER, S.
dc.contributor.authorMALLET, J.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, C.
dc.contributor.authorREY, R.
dc.contributor.authorSZOKE, A.
dc.contributor.authorURBACH, M.
dc.contributor.authorLEBOYER, M.
dc.contributor.authorLLORCA, P.M.
dc.contributor.authorLANÇON, C.
dc.contributor.authorBOYER, L.
dc.contributor.authorFOND, G.
dc.contributor.authorANDRE, M.
dc.contributor.authorANDRIEU-HALLER, C.
dc.contributor.authorBLANC, O.
dc.contributor.authorBOURGUIGNON, E.
dc.contributor.authorCHEREAU-BOUDET, I.
dc.contributor.authorDASSING, R.
dc.contributor.authorESSELIN, A.
dc.contributor.authorFOND, G.
dc.contributor.authorGABAYET, F.
dc.contributor.authorJARROIR, M.
dc.contributor.authorLACELLE, D.
dc.contributor.authorMETAIRIE, E.
dc.contributor.authorMICHEL, T.
dc.contributor.authorPETRUCCI, J.
dc.contributor.authorPIGNON, B.
dc.contributor.authorPERI, P.
dc.contributor.authorPORTALIER, C.
dc.contributor.authorROMAN, C.
dc.contributor.authorSCHORR, B.
dc.contributor.authorSZÖKE, A.
dc.contributor.authorTESSIER, A.
dc.contributor.authorWACHICHE, G.
dc.contributor.authorZINETTI-BERTSCHY, A.
dc.date.accessioned2023-05-17T07:14:17Z
dc.date.available2023-05-17T07:14:17Z
dc.date.issued2022-07
dc.identifier.issn0940-1334en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182171
dc.description.abstractEnParent history of severe mental illness (PHSMI) may have long-term consequences in adult offspring due to genetic and early environmental factors in preliminary studies. To compare the outcomes associated in subjects with PHSMI to those in patients without PHSMI. The participants with schizophrenia and schizoaffective disorders were recruited in the ongoing FACE-SZ cohort at a national level (10 expert centers) and evaluated with a 1-day-long standardized battery of clinician-rated scales and patient-reported outcomes. PHSMI was defined as history of schizophrenia or bipolar disorders in at least one parent and was included as explanatory variable in multivariate models. Of the 724 included patients, 78 (10.7%) subjects were classified in the PHSMI group. In multivariate analyses, PHSMI patients had a better insight into schizophrenia and the need for treatment and reported more often childhood trauma history compared to patients without PHSMI. More specifically, those with paternal history of SMI reported more severe outcomes (increased childhood physical and emotional abuses, comorbid major depression and psychiatric hospitalizations). PHSMI is associated with increased risk of childhood trauma, major depressive disorder and psychiatric hospitalization and better insight in individuals with schizophrenia. Specific public health prevention programs for parents with SMI should be developed to help protect children from pejorative psychiatric outcomes. PHSMI may also explain in part the association between better insight and increased depression in schizophrenia. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.subject.enPsychiatry
dc.subject.enMental heal
dc.subject.enSchizophrenia
dc.subject.enQuality of life
dc.subject.enMood disorders
dc.subject.enDepressive disorders
dc.title.enThe impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00406-022-01449-xen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35852617en_US
bordeaux.journalEuropean archives of psychiatry and clinical neuroscienceen_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionCNRS
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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