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The C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus?
| dc.rights.license | open | en_US |
| dc.contributor.author | ROCCHI, Cecilia | |
| dc.contributor.author | GOUET, Patrice | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PARISSI, Vincent | |
| dc.contributor.author | FIORINI, Francesca | |
| dc.date.accessioned | 2023-05-16T12:29:03Z | |
| dc.date.available | 2023-05-16T12:29:03Z | |
| dc.date.issued | 2022 | |
| dc.identifier.issn | 1999-4915 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182156 | |
| dc.description.abstractEn | Retroviral integrase is a multimeric enzyme that catalyzes the integration of reverse-transcribed viral DNA into the cellular genome. Beyond integration, the Human immunodeficiency virus type 1 (HIV-1) integrase is also involved in many other steps of the viral life cycle, such as reverse transcription, nuclear import, virion morphogenesis and proviral transcription. All these additional functions seem to depend on the action of the integrase C-terminal domain (CTD) that works as a molecular hub, interacting with many different viral and cellular partners. In this review, we discuss structural issues concerning the CTD, with particular attention paid to its interaction with nucleic acids. We also provide a detailed map of post-translational modifications and interaction with molecular partners. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | integrase | |
| dc.subject.en | HIV-1 | |
| dc.subject.en | CTD structure | |
| dc.subject.en | CTD-DNA interaction | |
| dc.subject.en | integrase molecular partners | |
| dc.title.en | The C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus? | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/v14071397 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie structurale [q-bio.BM] | en_US |
| bordeaux.journal | Viruses | en_US |
| bordeaux.page | 1397 | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03856882 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Viruses&rft.date=2022&rft.volume=14&rft.issue=7&rft.spage=1397&rft.epage=1397&rft.eissn=1999-4915&rft.issn=1999-4915&rft.au=ROCCHI,%20Cecilia&GOUET,%20Patrice&PARISSI,%20Vincent&FIORINI,%20Francesca&rft.genre=article |
