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dc.rights.licenseopenen_US
dc.contributor.authorROCCHI, Cecilia
dc.contributor.authorGOUET, Patrice
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorPARISSI, Vincent
dc.contributor.authorFIORINI, Francesca
dc.date.accessioned2023-05-16T12:29:03Z
dc.date.available2023-05-16T12:29:03Z
dc.date.issued2022
dc.identifier.issn1999-4915en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182156
dc.description.abstractEnRetroviral integrase is a multimeric enzyme that catalyzes the integration of reverse-transcribed viral DNA into the cellular genome. Beyond integration, the Human immunodeficiency virus type 1 (HIV-1) integrase is also involved in many other steps of the viral life cycle, such as reverse transcription, nuclear import, virion morphogenesis and proviral transcription. All these additional functions seem to depend on the action of the integrase C-terminal domain (CTD) that works as a molecular hub, interacting with many different viral and cellular partners. In this review, we discuss structural issues concerning the CTD, with particular attention paid to its interaction with nucleic acids. We also provide a detailed map of post-translational modifications and interaction with molecular partners.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enintegrase
dc.subject.enHIV-1
dc.subject.enCTD structure
dc.subject.enCTD-DNA interaction
dc.subject.enintegrase molecular partners
dc.title.enThe C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus?
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/v14071397en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologieen_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie structurale [q-bio.BM]en_US
bordeaux.journalVirusesen_US
bordeaux.page1397en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue7en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-03856882
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Viruses&rft.date=2022&rft.volume=14&rft.issue=7&rft.spage=1397&rft.epage=1397&rft.eissn=1999-4915&rft.issn=1999-4915&rft.au=ROCCHI,%20Cecilia&GOUET,%20Patrice&PARISSI,%20Vincent&FIORINI,%20Francesca&rft.genre=article


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