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dc.rights.licenseopenen_US
dc.contributor.authorKHALFALLAH, Olfa
dc.contributor.authorBARBOSA, Susana
dc.contributor.authorPHILLIPAT, Claire
dc.contributor.authorSLAMA, Remy
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
dc.contributor.authorHEUDE, Barbara
dc.contributor.authorGLAICHENHAUS, Nicolas
dc.contributor.authorDAVIDOVIC, Laetitia
dc.date.accessioned2023-05-15T07:36:39Z
dc.date.available2023-05-15T07:36:39Z
dc.date.issued2023-07-15
dc.identifier.issn1096-0953 (Electronic) 0013-9351 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182110
dc.description.abstractEnChildhood internalizing disorders refer to inwardly focused negative behaviours such as anxiety, depression, and somatic complains. Interactions between psychosocial, genetic, and environmental risk factors adversely impact neurodevelopment and can contribute to internalizing disorders. While prenatal exposure to single endocrine disruptors (EDs) is associated with internalizing behaviours in infants, the associations with prenatal exposure to ED in mixture remain poorly addressed. In addition, the biological mediators of EDs in mixture effects on internalizing behaviours remain unexplored. EDs do not only interfere with endocrine function, but also with immune function and inflammatory processes. Based on this body of evidence, we hypothetised that inflammation at birth is a plausible biological pathway through which prenatal exposure to EDs in mixture could operate to influence offspring internalizing behaviours. Based on the EDEN birth cohort, we investigated whether exposure to a mixture of EDs increased the odds of internalizing disorders in 459 boy infants at age 3, and whether the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α measured at birth are mediators of this effect. To determine both the joint and individual associations of prenatal exposure to EDs with infant internalizing behaviours and the possible mediating role of cytokines, we used the counterfactual hierarchical Bayesian Kernel Machine Regression (BKMR) regression-causal mediation analysis. We show that prenatal exposure to a complex mixture of EDs has limited effects on internalizing behaviours in boys at age 3. We also show that IL-1β, IL-6, and TNF-α are unlikely mediators or suppressors of ED mixture effects on internalizing behaviours in boys at age 3. Further studies on larger cohorts are warranted to refine the deleterious effects of EDs in mixtures on internalizing behaviours and identify possible mediating pathways.
dc.language.isoENen_US
dc.title.enCytokines as mediators of the associations of prenatal exposure to phenols, parabens, and phthalates with internalizing behaviours at age 3 in boys: A mixture exposure and mediation approach
dc.title.alternativeEnviron Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2023.115865en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37062478en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.volume229en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04097193
hal.version1
hal.date.transferred2023-05-15T07:36:41Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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