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Prediction of survival after lung transplantation at one year (SALTO cohort) using information available at different key time-points

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELAROUSSI, Yaniss
dc.contributor.authorHUSTACHE-CASTAING, Romain
dc.contributor.authorMAURY, Jean-Michel
dc.contributor.authorLEHOT, Laurent
dc.contributor.authorRODRIGUEZ, Arnaud
dc.contributor.authorDEMANT, Xavier
dc.contributor.authorROZE, Hadrien
dc.contributor.authorBRIOUDE, Geoffrey
dc.contributor.authorD'JOURNO, Xavier-Benoit
dc.contributor.authorDREVET, Gabrielle
dc.contributor.authorTRONC, Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
dc.contributor.authorJOUGON, Jacques
dc.contributor.authorTHOMAS, Pascal-Alexandre
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorTHUMEREL, Matthieu
dc.date.accessioned2023-05-13T09:21:06Z
dc.date.available2023-05-13T09:21:06Z
dc.date.issued2023-04-26
dc.identifier.issn1873-734X (Electronic) 1010-7940 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182092
dc.description.abstractEnBACKGROUND: Lung transplantation is the final treatment option for end-stage lung disease. In this study, we evaluated the individual risk of 1-year mortality at each stage of the lung transplantation process. METHODS: This was a retrospective analysis of patients undergoing bilateral lung transplantation between January 2014 and December 2019 in three French academic centers. Patients were randomly divided into development and validation cohorts. Three multivariable logistic regression models of 1-year mortality were applied (A) at recipient registration, (B) the graft allocation, and (C) after surgery. The 1-year mortality was predicted for individual patients assigned to three risk groups at time points A-C. RESULTS: The study population consisted of 478 patients with a mean (SD) age of 49.0 (14.3) years. The 1-year mortality rate was 23.0%. There were no significant differences in patient characteristics between the development (n = 319) and validation (n = 159) cohorts. The models analyzed recipient, donor, and intraoperative variables. The discriminatory power (area under the receiver operating characteristic curve) was 0.67 (0.62-0.73), 0.70 (0.63-0.77), and 0.82 (0.77-0.88), respectively, in the development cohort, 0.74 (0.64-0.85), 0.76 (0.66-0.86) and 0.87 (0.79 - 0.95), respectively, in the validation cohort. Survival rates were significantly different among the low- (< 15%), intermediate- (15%-45%), and high-risk (> 45%) groups in both cohorts. CONCLUSIONS: Risk prediction models allow estimation of the 1-year mortality risk of individual patients during the lung transplantation process. These models may help caregivers identify high-risk patients at times A-C, and reduce the risk at subsequent time-points.
dc.language.isoENen_US
dc.subject.enLung transplantation
dc.subject.enpredictive model
dc.subject.ensurvival
dc.title.enPrediction of survival after lung transplantation at one year (SALTO cohort) using information available at different key time-points
dc.title.alternativeEur J Cardiothorac Surgen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ejcts/ezad167en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
dc.identifier.pubmed37099715en_US
bordeaux.journalEuropean Journal of Cardio-Thoracic Surgeryen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04096679
hal.version1
hal.date.transferred2023-05-13T09:44:02Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=European%20Journal%20of%20Cardio-Thoracic%20Surgery&amp;rft.date=2023-04-26&amp;rft.eissn=1873-734X%20(Electronic)%201010-7940%20(Linking)&amp;rft.issn=1873-734X%20(Electronic)%201010-7940%20(Linking)&amp;rft.au=BELAROUSSI,%20Yaniss&amp;HUSTACHE-CASTAING,%20Romain&amp;MAURY,%20Jean-Michel&amp;LEHOT,%20Laurent&amp;RODRIGUEZ,%20Arnaud&amp;rft.genre=article


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