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Innovative molecular-based fluorescent nanoparticles for multicolor single particle tracking in cells

hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDANIEL, Jonathan
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorGODIN, Antoine
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPALAYRET, Matthieu
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorLOUNIS, Brahim
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBLANCHARD-DESCE, Mireille
dc.date.accessioned2023-05-12T10:54:30Z
dc.date.available2023-05-12T10:54:30Z
dc.date.issued2016
dc.identifier.issn0022-3727
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181914
dc.description.abstractEnBased on an original molecular-based design we present bright and photostable fluorescent organic nanoparticles (FONs) with an excellent colloidal stability in various aqueous environments. Near-infrared emitting and green emitting FONs were prepared using a simple and robust protocol. Both types of FONs could be simultaneously imaged at the single-particle level in solution as well as in biological environments using a monochromatic excitation and a dual-color fluorescence microscope. No evidence of acute cytotoxicity was found upon incubation of live cells with mixed solutions of FONs, and both types of nanoparticles were found internalized in the cells where their movements could be simultaneously tracked at video-rate up to minutes. These fluorescent FONs open a novel non-toxic alternative to existing nanoparticles for imaging biological structures, compatible with live-cell experiments and specially fitted for multicolor single particle tracking.
dc.language.isoen
dc.publisherIOP Publishing
dc.title.enInnovative molecular-based fluorescent nanoparticles for multicolor single particle tracking in cells
dc.typeArticle de revue
dc.identifier.doi10.1088/0022-3727/49/8/084002
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalJournal of Physics D: Applied Physics
bordeaux.page84002 - 84002
bordeaux.volume49
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01390058
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01390058v1
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