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Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorDEWULF, Melissa
hal.structure.identifierUniversity of Warwick [Coventry]
dc.contributor.authorVASCO KÖSTER, Darius
hal.structure.identifierIndian Institute of Science Education and Research Kolbata [IISER Kolkata]
dc.contributor.authorSINHA, Bidisha
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorVIARIS DE LESEGNO, Christine
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorCHAMBON, Valérie
hal.structure.identifierCentre de recherche en Myologie – U974 SU-INSERM
dc.contributor.authorBIGOT, Anne
hal.structure.identifierCentre de recherche en Myologie – U974 SU-INSERM
dc.contributor.authorBENSALAH, Mona
hal.structure.identifierCentre de recherche en Myologie – U974 SU-INSERM
dc.contributor.authorNEGRONI, Elisa
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorTARDIF, Nicolas
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
hal.structure.identifierLaboratoire Physico-Chimie Curie [Institut Curie] [PCC]
hal.structure.identifierUniversity of Wrocław [Poland] [UWr]
dc.contributor.authorPODKALICKA, Joanna
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorJOHANNES, Ludger
hal.structure.identifierInstitut d'Optique Graduate School [IOGS]
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorNASSOY, Pierre
hal.structure.identifierCentre de recherche en Myologie – U974 SU-INSERM
dc.contributor.authorBUTLER-BROWNE, Gillian
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorLAMAZE, Christophe
hal.structure.identifierChimie biologique des membranes et ciblage thérapeutique [CBMCT - UMR 3666 / U1143]
dc.contributor.authorBLOUIN, Cedric
dc.date.accessioned2023-05-12T10:47:45Z
dc.date.available2023-05-12T10:47:45Z
dc.date.issued2019
dc.identifier.issn2041-1723
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181745
dc.description.abstractEnCaveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene cause different types of myopathies with altered membrane integrity and repair, expression of muscle proteins, and regulation of signaling pathways. We show here that myotubes from patients bearing the CAV3 P28L and R26Q mutations present a dramatic decrease of caveolae at the plasma membrane, resulting in abnormal response to mechanical stress. Mutant myotubes are unable to buffer the increase in membrane tension induced by mechanical stress. This results in impaired regulation of the IL6/STAT3 signaling pathway leading to its constitutive hyperactivation and increased expression of muscle genes. These defects are fully reversed by reassembling functional caveolae through expression of caveolin-3. Our study reveals that under mechanical stress the regulation of mechan-oprotection by caveolae is directly coupled with the regulation of IL6/STAT3 signaling in muscle cells and that this regulation is absent in Cav3-associated dystrophic patients.
dc.language.isoen
dc.publisherNature Publishing Group
dc.title.enDystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
dc.typeArticle de revue
dc.identifier.doi10.1038/s41467-019-09405-5
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire
bordeaux.journalNature Communications
bordeaux.page1974
bordeaux.volume10
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02129168
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02129168v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2019&rft.volume=10&rft.spage=1974&rft.epage=1974&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=DEWULF,%20Melissa&VASCO%20K%C3%96STER,%20Darius&SINHA,%20Bidisha&VIARIS%20DE%20LESEGNO,%20Christine&CHAMBON,%20Val%C3%A9rie&rft.genre=article


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