Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | SORIA, Federico | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | PAVIOLO, Chiara | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | DOUDNIKOFF, Evelyne | |
dc.contributor.author | AROTCARENA, Marie-Laure | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | LEE, Antony | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | DANNÉ, Noémie | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | MANDAL, Amit Kumar | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | GOSSET, Philippe | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | DEHAY, Benjamin | |
hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
dc.contributor.author | GROC, Laurent | |
hal.structure.identifier | Laboratoire Photonique, Numérique et Nanosciences [LP2N] | |
dc.contributor.author | COGNET, Laurent | |
hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
dc.contributor.author | BÉZARD, Erwan | |
dc.date.accessioned | 2023-05-12T10:40:44Z | |
dc.date.available | 2023-05-12T10:40:44Z | |
dc.date.issued | 2020-12 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/181608 | |
dc.description.abstractEn | In recent years, exploration of the brain extracellular space (ECS) has made remarkable progress, including nanoscopic characterizations. However, whether ECS precise conformation is altered during brain pathology remains unknown. Here we study the nanoscale organization of pathological ECS in adult mice under degenerative conditions. Using electron microscopy in cryofixed tissue and single nanotube tracking in live brain slices combined with super-resolution imaging analysis, we find enlarged ECS dimensions and increased nanoscale diffusion after α-synuclein-induced neurodegeneration. These animals display a degraded hyaluronan matrix in areas close to reactive microglia. Furthermore, experimental hyaluronan depletion in vivo reduces dopaminergic cell loss and α-synuclein load, induces microgliosis and increases ECS diffusivity, highlighting hyaluronan as diffusional barrier and local tissue organizer. These findings demonstrate the interplay of ECS, extracellular matrix and glia in pathology, unraveling ECS features relevant for the α-synuclein propagation hypothesis and suggesting matrix manipulation as a disease-modifying strategy. | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.title.en | Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1038/s41467-020-17328-9 | |
dc.subject.hal | Sciences du Vivant [q-bio] | |
bordeaux.journal | Nature Communications | |
bordeaux.page | 3440 | |
bordeaux.volume | 11 | |
bordeaux.hal.laboratories | Laboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | inserm-02904850 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//inserm-02904850v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2020-12&rft.volume=11&rft.issue=1&rft.spage=3440&rft.epage=3440&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=SORIA,%20Federico&PAVIOLO,%20Chiara&DOUDNIKOFF,%20Evelyne&AROTCARENA,%20Marie-Laure&LEE,%20Antony&rft.genre=article |
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