Show simple item record

Intrinsically stealth fluorescent organic nanoparticles made of articulated bis-dipolar dyes for single particle tracking

hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorROSENDALE, Morgane
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorCLERMONT, Guillaume
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDANIEL, Jonathan
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPAVIOLO, Chiara
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorVERLHAC, Jean-Baptiste
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBLANCHARD-DESCE, Mireille
dc.date.accessioned2023-05-12T10:32:58Z
dc.date.available2023-05-12T10:32:58Z
dc.date.created2020
dc.date.issued2020
dc.date.conference2020-04-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181450
dc.description.abstractEnLuminescent nanoparticles are becoming fundamental tools to the field of bioimaging. The optimization of their size, brightness and stability is key for applications ranging from contrast agent assisted surgery to diagnosis and therapeutics. A plethora of formulations have been documented which can be split into inorganic, organic and hybrid categories. While each class has their own advantages and limitations, controlling the interactions occurring between nanoparticles and cellular membranes is of the utmost importance. In particular, a major challenge for various applications, especially molecular imaging of membrane receptors, is to prevent non-specific interactions. Towards this goal, popular strategies based on coating nanoparticles with PEG or zwitterionic moieties have been developed to yield stealth nanoparticles. In this study, we present a series of spontaneously water-soluble and stealth organic nanoparticles. These fluorescent nanoparticles, made from original articulated bis-dipolar dyes, show vanishing interactions with living cells as bare nanoparticles. Moreover, thanks to their brightness and stability, they can be tracked as isolated single emitters in aqueous environments. These stealth nanoparticles thus hold promise for molecular imaging of specific membrane receptors, such as neuronal receptors, after bioconjugation with dedicated targeting agents.
dc.language.isoen
dc.publisherSPIE
dc.source.titleProceedings of SPIE
dc.subject.enLuminescence
dc.subject.enmolecular-based nanoparticles
dc.subject.ensingle particle tracking
dc.subject.enstealthiness
dc.title.enIntrinsically stealth fluorescent organic nanoparticles made of articulated bis-dipolar dyes for single particle tracking
dc.typeCommunication dans un congrès avec actes
dc.identifier.doi10.1117/12.2560140
dc.subject.halChimie/Matériaux
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
dc.subject.halChimie
bordeaux.page05
bordeaux.volume11360
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.countryFR
bordeaux.title.proceedingSPIE Photonics Europe
bordeaux.conference.cityOnline Only
bordeaux.peerReviewedoui
hal.identifierhal-02548137
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02548137v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Proceedings%20of%20SPIE&rft.date=2020&rft.volume=11360&rft.spage=05&rft.epage=05&rft.au=ROSENDALE,%20Morgane&CLERMONT,%20Guillaume&DANIEL,%20Jonathan&PAVIOLO,%20Chiara&COGNET,%20Laurent&rft.genre=proceeding


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record