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Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses

hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPAVIOLO, Chiara
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorFERREIRA, Joana
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorLEE, Antony
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorHUNTER, Daniel
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorCALARESU, Ivo
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorNANDI, Somen
hal.structure.identifierInterdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
dc.contributor.authorGROC, Laurent
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
dc.date.accessioned2023-05-12T10:31:13Z
dc.date.available2023-05-12T10:31:13Z
dc.date.issued2022-08-29
dc.identifier.issn1530-6984
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181402
dc.description.abstractEnWe provide evidence of a local synaptic nanoenvironment in the brain extracellular space (ECS) lying within 500 nm of postsynaptic densities. To reveal this brain compartment, we developed a correlative imaging approach dedicated to thick brain tissue based on single-particle tracking of individual fluorescent single wall carbon nanotubes (SWCNTs) in living samples and on speckle-based HiLo microscopy of synaptic labels. We show that the extracellular space around synapses bears specific properties in terms of morphology at the nanoscale and inner diffusivity. We finally show that the ECS juxta-synaptic region changes its diffusion parameters in response to neuronal activity, indicating that this nanoenvironment might play a role in the regulation of brain activity.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enSingle-walled carbon nanotubes
dc.subject.enbrain extracellular space
dc.subject.ensingle particle tracking
dc.subject.ensuperlocalization microscopy
dc.subject.enorganotypic brain slices
dc.subject.ensynapses
dc.subject.encorrelative imaging
dc.title.enNear-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.nanolett.1c04259
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalNano Letters
bordeaux.page6849 - 6856
bordeaux.volume22
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.issue17
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03852991
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03852991v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nano%20Letters&rft.date=2022-08-29&rft.volume=22&rft.issue=17&rft.spage=6849%20-%206856&rft.epage=6849%20-%206856&rft.eissn=1530-6984&rft.issn=1530-6984&rft.au=PAVIOLO,%20Chiara&FERREIRA,%20Joana&LEE,%20Antony&HUNTER,%20Daniel&CALARESU,%20Ivo&rft.genre=article


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