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Gene expression patterns and sequence polymorphisms associated with mosquito resistance to Bacillus thuringiensis israelensis toxins

hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA]
dc.contributor.authorDESPRES, Laurence
hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA]
dc.contributor.authorSTALINSKI, Renaud
hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA]
dc.contributor.authorTETREAU, Guillaume
hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA]
dc.contributor.authorPARIS, Margot
hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA]
dc.contributor.authorBONIN, Aurélie
hal.structure.identifierInstitut des Sciences Analytiques [ISA]
dc.contributor.authorNAVRATIL, Vincent
hal.structure.identifierASTRIUM
dc.contributor.authorREYNAUD, Stephane
hal.structure.identifierAménagement, Développement, Environnement, Santé et Sociétés [ADES]
dc.contributor.authorDAVID, Jean-Philippe
dc.date.issued2014
dc.identifier.issn1471-2164
dc.description.abstractEnBackground: Despite the intensive use of Bacillus thuringiensis israelensis (Bti) toxins for mosquito control, little is known about the long term effect of exposure to this cocktail of toxins on target mosquito populations. In contrast to the many cases of resistance to Bacillus thuringiensis Cry toxins observed in other insects, there is no evidence so far for Bti resistance evolution in field mosquito populations. High fitness costs measured in a Bti selected mosquito laboratory strain suggest that evolving resistance to Bti is costly. The aim of the present study was to identify transcription level and polymorphism variations associated with resistance to Bti toxins in the dengue vector Aedes aegypti. We used RNA sequencing (RNA-seq) for comparing a laboratory-selected strain showing elevated resistance to Bti toxins and its parental non-selected susceptible strain. As the resistant strain displayed two marked larval development phenotypes (slow and normal), each phenotype was analyzed separately in order to evidence potential links between resistance mechanisms and mosquito life-history traits.
dc.language.isoen
dc.publisherBioMed Central
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enGene expression patterns and sequence polymorphisms associated with mosquito resistance to Bacillus thuringiensis israelensis toxins
dc.typeArticle de revue
dc.identifier.doi10.1186/1471-2164-15-926
dc.subject.halSciences du Vivant [q-bio]/Biodiversité/Evolution [q-bio.PE]
bordeaux.journalBMC Genomics
bordeaux.page926
bordeaux.volume15
bordeaux.issue1
bordeaux.peerReviewedoui
hal.identifierhal-01996612
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01996612v1
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