Conservation of locomotion-induced oculomotor activity through evolution in mammals.
| dc.rights.license | open | en_US |
| dc.contributor.author | FRANCA DE BARROS, Filipa | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | BACQUE CAZENAVE, Julien | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | TAILLEBUIS, Coralie | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COURTAND, Gilles | |
| dc.contributor.author | MANUEL, Marin | |
| dc.contributor.author | BRAS, Helene | |
| dc.contributor.author | TAGLIABUE, Michele | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | COMBES, Denis
ORCID: 0000-0003-3732-7261 | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | LAMBERT, Francois | |
| dc.contributor.author | BERANECK, Mathieu | |
| dc.date.accessioned | 2023-05-03T07:28:11Z | |
| dc.date.available | 2023-05-03T07:28:11Z | |
| dc.date.issued | 2022-01-24 | |
| dc.identifier.issn | 1879-0445 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/173239 | |
| dc.description.abstractEn | Efference copies are neural replicas of motor outputs used to anticipate the sensory consequences of a self-generated motor action or to coordinate neural networks involved in distinct motor behaviors. An established example of this motor-to-motor coupling is the efference copy of the propulsive motor command, which supplements classical visuo-vestibular reflexes to ensure gaze stabilization during amphibian larval locomotion. Such feedforward replica of spinal pattern-generating circuits produces a spino-extraocular motor coupled activity that evokes eye movements, spatiotemporally coordinated to tail undulation independently of any sensory signal. Exploiting the developmental stages of the frog, studies in metamorphing Xenopus demonstrated the persistence of this spino-extraocular motor command in adults and its developmental adaptation to tetrapodal locomotion. Here, we demonstrate for the first time the existence of a comparable locomotor-to-ocular motor coupling in the mouse. In neonates, ex vivo nerve recordings of brainstem-spinal cord preparations reveal a spino-extraocular motor coupled activity similar to the one described in Xenopus. In adult mice, trans-synaptic rabies virus injections in lateral rectus eye muscle label cervical spinal cord neurons closely connected to abducens motor neurons. Finally, treadmill-elicited locomotion in decerebrated preparations evokes rhythmic eye movements in synchrony with the limb gait pattern. Overall, our data are evidence for the conservation of locomotor-induced eye movements in vertebrate lineages. Thus, in mammals as in amphibians, CPG-efference copy feedforward signals might interact with sensory feedback to ensure efficient gaze control during locomotion. | |
| dc.description.sponsorship | Corrélats neurophysiologiques de l'évolution et du développement des stratégies de stabilisation du regard pendant la locomotion chez les vertébrés - ANR-15-CE32-0007 | en_US |
| dc.description.sponsorship | Université de Paris | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Animals | |
| dc.subject.en | Eye Movements | |
| dc.subject.en | Locomotion | |
| dc.subject.en | Mammals | |
| dc.subject.en | Mice | |
| dc.subject.en | Motor Neurons | |
| dc.subject.en | Reflex | |
| dc.subject.en | Vestibulo-Ocular | |
| dc.subject.en | Spinal Cord | |
| dc.subject.en | Xenopus laevis | |
| dc.title.en | Conservation of locomotion-induced oculomotor activity through evolution in mammals. | |
| dc.title.alternative | Curr Biol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.cub.2021.11.022 | en_US |
| dc.identifier.pubmed | 34856124 | en_US |
| bordeaux.journal | Current Biology - CB | en_US |
| bordeaux.page | 453-461.e4 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | MotoPSYN | en_US |
| bordeaux.team | DN3 | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.date=2022-01-24&rft.volume=32&rft.issue=2&rft.spage=453-461.e4&rft.epage=453-461.e4&rft.eissn=1879-0445&rft.issn=1879-0445&rft.au=FRANCA%20DE%20BARROS,%20Filipa&BACQUE%20CAZENAVE,%20Julien&TAILLEBUIS,%20Coralie&COURTAND,%20Gilles&MANUEL,%20Marin&rft.genre=article |
