Show simple item record

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorOLECHOWSKI, Anne
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorGRANDEMANGE, Raphael
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCARDOIT, Laura
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOURTY, Elric
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLAMBERT, Francois
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLE RAY, Didier
ORCID: 0000-0003-2089-9861
IDREF: 141904275
dc.date.accessioned2023-05-02T13:21:48Z
dc.date.available2023-05-02T13:21:48Z
dc.date.issued2020-02-01
dc.identifier.issn0022-3751en_US
dc.identifier.urioai:crossref.org:10.1113/jp278599
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173235
dc.description.abstractEnKey points - Vestibulospinal reflexes participate in postural control. How this is achieved has not been investigated fully. - We combined electrophysiological, neuroanatomical and imaging techniques to decipher the vestibulospinal network controlling the activation of back and limb muscles responsible for postural adjustments. - We describe two distinct pathways activating either thoracic postural motoneurons alone or thoracic and lumbar motoneurons together, with the latter co-ordinating specifically hindlimb extensors and postural back muscles. In vertebrates, trunk postural stabilization is known to rely mainly on direct vestibulospinal inputs on spinal axial motoneurons. However, a substantial role of central spinal commands ascending from lumbar segments is not excluded during active locomotion. In the adult Xenopus, a lumbar drive dramatically overwhelms the descending inputs onto thoracic postural motoneurons during swimming. Given that vestibulospinal fibres also project onto the lumbar segments that shelter the locomotor generators, we investigated whether such a lumbo-thoracic pathway may relay vestibular information and consequently, also be involved in the control of posture at rest. We show that thoracic postural motoneurons exhibit particular dendritic spatial organization allowing them to gather information from both sides of the cord. In response to passive head motion, these motoneurons display both early and delayed discharges, with the latter occurring in phase with ipsilateral hindlimb extensor bursts. We demonstrate that both vestibulospinal and lumbar ascending fibres converge onto postural motoneurons, and that thoracic motoneurons monosynaptically respond to the electrical stimulation of either pathway. Finally, we show that vestibulospinal fibres project to and activate lumbar interneurons with thoracic projections. Taken together, our results complete the scheme of the vestibulospinal control of posture by illustrating the existence of a novel, indirect pathway, which implicates lumbar interneurons relaying vestibular inputs to thoracic motoneurons, and participating in global body postural stabilization in the absence of active locomotion.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enLumbar
dc.subject.enMotoneuron
dc.subject.enPosture
dc.subject.enSpinal cord
dc.subject.enThoracic
dc.subject.enVestibular
dc.subject.enXenopus
dc.title.enFunctional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus
dc.typeArticle de revueen_US
dc.identifier.doi10.1113/jp278599en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed31834949en_US
bordeaux.journalThe Journal of Physiologyen_US
bordeaux.page817-838en_US
bordeaux.volume598en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamDN3en_US
bordeaux.teamMotoPSYNen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20Physiology&rft.date=2020-02-01&rft.volume=598&rft.issue=4&rft.spage=817-838&rft.epage=817-838&rft.eissn=0022-3751&rft.issn=0022-3751&rft.au=OLECHOWSKI,%20Anne&GRANDEMANGE,%20Raphael&CARDOIT,%20Laura&COURTY,%20Elric&LAMBERT,%20Francois&rft.genre=article


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record