Water intake and progression of chronic kidney disease: the CKD-REIN cohort study
| dc.rights.license | open | en_US |
| dc.contributor.author | WAGNER, Sandra | |
| dc.contributor.author | MERKLING, Thomas | |
| dc.contributor.author | METZGER, Marie | |
| dc.contributor.author | BANKIR, Lise | |
| dc.contributor.author | LAVILLE, Maurice | |
| dc.contributor.author | FRIMAT, Luc | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | COMBE, Christian
ORCID: 0000-0002-0360-573X IDREF: 58708871 | |
| dc.contributor.author | JACQUELINET, Christian | |
| dc.contributor.author | FOUQUE, Denis | |
| dc.contributor.author | MASSY, Ziad A | |
| dc.contributor.author | STENGEL, Bénédicte | |
| dc.contributor.author | FOR THE CKD-REIN STUDY GROUP | |
| dc.date.accessioned | 2023-04-26T07:26:59Z | |
| dc.date.available | 2023-04-26T07:26:59Z | |
| dc.date.issued | 2022-04-01 | |
| dc.identifier.issn | 0931-0509 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/173195 | |
| dc.description.abstractEn | Optimal daily water intake to prevent chronic kidney disease (CKD) progression is unknown. Taking the kidney’s urine-concentrating ability into account, we studied the relation of kidney outcomes in patients with CKD to total and plain water intake and urine volume.Including 1265 CKD patients [median age 69 years; mean estimated glomerular filtration rate (eGFR) 32 mL/min/1.73 m2] from the Chronic Kidney Disease–Renal Epidemiology and Information Network cohort (2013–19), we assessed fluid intake at baseline interviews, collected 24-h urine volumes and estimated urine osmolarity (eUosm). Using Cox and then linear mixed models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for kidney failure and eGFR decline associated with hydration markers, adjusting for CKD progression risk factors and eUosm.Patients’ median daily intake was 2.0 L [interquartile range (IQR) 1.6–2.6] for total water and 1.5 L (1–1.7) for plain water, median urine volume was 1.9 L/24 h (IQR 1.6–2.4) and mean eUosm was 374 ± 104 mosm/L. Neither total water intake nor urine volume was associated with either kidney outcome. Kidney failure risk increased significantly with decreasing eUosm ˂292 mosm/L. Adjusted HRs (95% CIs) for kidney failure associated with plain water intake were 1.88 (1.02–3.47), 1.59 (1.06–2.38), 1.76 (0.95–3.24) and 1.55 (1.03–2.32) in patients drinking <0.5, 0.5–1.0, 1.5–2.0 and >2.0 L/day compared with those drinking 1.0–1.5 L/day. High plain water intake was also significantly associated with faster eGFR decline.In patients with CKD, the relation between plain water intake and progression to kidney failure appears to be U-shaped. Both low and high intake may not be beneficial in CKD. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | kidney failure | |
| dc.subject.en | kidney function | |
| dc.subject.en | urine osmolarity | |
| dc.subject.en | urine volume | |
| dc.subject.en | water intake | |
| dc.title.en | Water intake and progression of chronic kidney disease: the CKD-REIN cohort study | |
| dc.title.alternative | Nephrology Dialysis Transplantation | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ndt/gfab036 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| bordeaux.journal | Nephrology Dialysis Transplantation | en_US |
| bordeaux.page | 730-739 | en_US |
| bordeaux.volume | 37 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nephrology%20Dialysis%20Transplantation&rft.date=2022-04-01&rft.volume=37&rft.issue=4&rft.spage=730-739&rft.epage=730-739&rft.eissn=0931-0509&rft.issn=0931-0509&rft.au=WAGNER,%20Sandra&MERKLING,%20Thomas&METZGER,%20Marie&BANKIR,%20Lise&LAVILLE,%20Maurice&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||