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dc.rights.licenseopenen_US
dc.contributor.authorWAGNER, Sandra
dc.contributor.authorMERKLING, Thomas
dc.contributor.authorMETZGER, Marie
dc.contributor.authorBANKIR, Lise
dc.contributor.authorLAVILLE, Maurice
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMBE, Christian
ORCID: 0000-0002-0360-573X
IDREF: 58708871
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorMASSY, Ziad A
dc.contributor.authorSTENGEL, Bénédicte
dc.contributor.authorFOR THE CKD-REIN STUDY GROUP
dc.date.accessioned2023-04-26T07:26:59Z
dc.date.available2023-04-26T07:26:59Z
dc.date.issued2022-04-01
dc.identifier.issn0931-0509en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173195
dc.description.abstractEnOptimal daily water intake to prevent chronic kidney disease (CKD) progression is unknown. Taking the kidney’s urine-concentrating ability into account, we studied the relation of kidney outcomes in patients with CKD to total and plain water intake and urine volume.Including 1265 CKD patients [median age 69 years; mean estimated glomerular filtration rate (eGFR) 32 mL/min/1.73 m2] from the Chronic Kidney Disease–Renal Epidemiology and Information Network cohort (2013–19), we assessed fluid intake at baseline interviews, collected 24-h urine volumes and estimated urine osmolarity (eUosm). Using Cox and then linear mixed models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for kidney failure and eGFR decline associated with hydration markers, adjusting for CKD progression risk factors and eUosm.Patients’ median daily intake was 2.0 L [interquartile range (IQR) 1.6–2.6] for total water and 1.5 L (1–1.7) for plain water, median urine volume was 1.9 L/24 h (IQR 1.6–2.4) and mean eUosm was 374 ± 104 mosm/L. Neither total water intake nor urine volume was associated with either kidney outcome. Kidney failure risk increased significantly with decreasing eUosm ˂292 mosm/L. Adjusted HRs (95% CIs) for kidney failure associated with plain water intake were 1.88 (1.02–3.47), 1.59 (1.06–2.38), 1.76 (0.95–3.24) and 1.55 (1.03–2.32) in patients drinking <0.5, 0.5–1.0, 1.5–2.0 and >2.0 L/day compared with those drinking 1.0–1.5  L/day. High plain water intake was also significantly associated with faster eGFR decline.In patients with CKD, the relation between plain water intake and progression to kidney failure appears to be U-shaped. Both low and high intake may not be beneficial in CKD.
dc.language.isoENen_US
dc.subject.enkidney failure
dc.subject.enkidney function
dc.subject.enurine osmolarity
dc.subject.enurine volume
dc.subject.enwater intake
dc.title.enWater intake and progression of chronic kidney disease: the CKD-REIN cohort study
dc.title.alternativeNephrology Dialysis Transplantationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ndt/gfab036en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalNephrology Dialysis Transplantationen_US
bordeaux.page730-739en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nephrology%20Dialysis%20Transplantation&rft.date=2022-04-01&rft.volume=37&rft.issue=4&rft.spage=730-739&rft.epage=730-739&rft.eissn=0931-0509&rft.issn=0931-0509&rft.au=WAGNER,%20Sandra&MERKLING,%20Thomas&METZGER,%20Marie&BANKIR,%20Lise&LAVILLE,%20Maurice&rft.genre=article


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